Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule
Pneumocystis pneumonia is a life threatening infection that usually presents with diffuse bilateral ground-glass infiltrates in immunocompromised patients. We report a case of a single nodular granulomatous Pneumocystis pneumonia in a male with diffuse large B-cell lymphoma after R-CHOP therapy. He...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/1873237 |
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| author | Krunal Bharat Patel James Benjamin Gleason Maria Julia Diacovo Nydia Martinez-Galvez |
| author_facet | Krunal Bharat Patel James Benjamin Gleason Maria Julia Diacovo Nydia Martinez-Galvez |
| author_sort | Krunal Bharat Patel |
| collection | DOAJ |
| description | Pneumocystis pneumonia is a life threatening infection that usually presents with diffuse bilateral ground-glass infiltrates in immunocompromised patients. We report a case of a single nodular granulomatous Pneumocystis pneumonia in a male with diffuse large B-cell lymphoma after R-CHOP therapy. He presented with symptoms of productive cough, dyspnea, and right-sided pleuritic chest pain that failed to resolve despite treatment with multiple antibiotics. Chest X-ray revealed right lower lobe atelectasis and CT of chest showed development of 2 cm nodular opacity with ground-glass opacities. Patient underwent bronchoscopy and biopsy that revealed granulomatous inflammation in a background of organizing pneumonia pattern with negative cultures. Respiratory symptoms resolved but the solitary nodular opacity increased in size prompting a surgical wedge resection which revealed granulomatous Pneumocystis pneumonia infection. This case is the third documented report of Pneumocystis pneumonia infection within a solitary pulmonary nodule in an individual with hematologic neoplasm. Although Pneumocystis pneumonia most commonly occurs in patients with HIV/acquired immunodeficiency syndrome and with diffuse infiltrates, the diagnosis should not be overlooked when only a solitary nodule is present. |
| format | Article |
| id | doaj-art-560fbcec04154b42820449fe616f17c6 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-560fbcec04154b42820449fe616f17c62025-02-03T01:09:25ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/18732371873237Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary NoduleKrunal Bharat Patel0James Benjamin Gleason1Maria Julia Diacovo2Nydia Martinez-Galvez3Department of Pulmonary & Critical Care Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Pulmonary & Critical Care Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Pathology, Cleveland Clinic Florida, Weston, FL, USADepartment of Pulmonary & Critical Care Medicine, Cleveland Clinic Florida, Weston, FL, USAPneumocystis pneumonia is a life threatening infection that usually presents with diffuse bilateral ground-glass infiltrates in immunocompromised patients. We report a case of a single nodular granulomatous Pneumocystis pneumonia in a male with diffuse large B-cell lymphoma after R-CHOP therapy. He presented with symptoms of productive cough, dyspnea, and right-sided pleuritic chest pain that failed to resolve despite treatment with multiple antibiotics. Chest X-ray revealed right lower lobe atelectasis and CT of chest showed development of 2 cm nodular opacity with ground-glass opacities. Patient underwent bronchoscopy and biopsy that revealed granulomatous inflammation in a background of organizing pneumonia pattern with negative cultures. Respiratory symptoms resolved but the solitary nodular opacity increased in size prompting a surgical wedge resection which revealed granulomatous Pneumocystis pneumonia infection. This case is the third documented report of Pneumocystis pneumonia infection within a solitary pulmonary nodule in an individual with hematologic neoplasm. Although Pneumocystis pneumonia most commonly occurs in patients with HIV/acquired immunodeficiency syndrome and with diffuse infiltrates, the diagnosis should not be overlooked when only a solitary nodule is present.http://dx.doi.org/10.1155/2016/1873237 |
| spellingShingle | Krunal Bharat Patel James Benjamin Gleason Maria Julia Diacovo Nydia Martinez-Galvez Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule Case Reports in Infectious Diseases |
| title | Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule |
| title_full | Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule |
| title_fullStr | Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule |
| title_full_unstemmed | Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule |
| title_short | Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule |
| title_sort | pneumocystis pneumonia presenting as an enlarging solitary pulmonary nodule |
| url | http://dx.doi.org/10.1155/2016/1873237 |
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