Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.
Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endo...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-03-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014741&type=printable |
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| author | Lucy B Ochola Bethsheba R Siddondo Harold Ocholla Siana Nkya Eva N Kimani Thomas N Williams Johnstone O Makale Anne Liljander Britta C Urban Pete C Bull Tadge Szestak Kevin Marsh Alister G Craig |
| author_facet | Lucy B Ochola Bethsheba R Siddondo Harold Ocholla Siana Nkya Eva N Kimani Thomas N Williams Johnstone O Makale Anne Liljander Britta C Urban Pete C Bull Tadge Szestak Kevin Marsh Alister G Craig |
| author_sort | Lucy B Ochola |
| collection | DOAJ |
| description | Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases. |
| format | Article |
| id | doaj-art-560b6f168c5a46409f8e822494c2c673 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-560b6f168c5a46409f8e822494c2c6732025-01-24T05:31:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1474110.1371/journal.pone.0014741Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.Lucy B OcholaBethsheba R SiddondoHarold OchollaSiana NkyaEva N KimaniThomas N WilliamsJohnstone O MakaleAnne LiljanderBritta C UrbanPete C BullTadge SzestakKevin MarshAlister G CraigOur understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014741&type=printable |
| spellingShingle | Lucy B Ochola Bethsheba R Siddondo Harold Ocholla Siana Nkya Eva N Kimani Thomas N Williams Johnstone O Makale Anne Liljander Britta C Urban Pete C Bull Tadge Szestak Kevin Marsh Alister G Craig Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS ONE |
| title | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. |
| title_full | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. |
| title_fullStr | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. |
| title_full_unstemmed | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. |
| title_short | Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. |
| title_sort | specific receptor usage in plasmodium falciparum cytoadherence is associated with disease outcome |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014741&type=printable |
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