Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic...
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2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/7402469 |
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| author | Nadia Sawicka-Gutaj Ariadna Zybek-Kocik Aleksandra Klimowicz Michał Kloska Dorota Mańkowska-Wierzbicka Jerzy Sowiński Marek Ruchała |
| author_facet | Nadia Sawicka-Gutaj Ariadna Zybek-Kocik Aleksandra Klimowicz Michał Kloska Dorota Mańkowska-Wierzbicka Jerzy Sowiński Marek Ruchała |
| author_sort | Nadia Sawicka-Gutaj |
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| description | We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p=0.0001). Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β=0.1014; p=0.003), FT4 (β=0.05412; p=0.048), FT3 (β=0.05242; p=0.038), and TPOAb (β=0.0002; p=0.0025), and the relationships were further confirmed in the multivariate regression analysis. |
| format | Article |
| id | doaj-art-5603461478b841138117c698cb6431ba |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-5603461478b841138117c698cb6431ba2025-02-03T05:54:38ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/74024697402469Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase AntibodiesNadia Sawicka-Gutaj0Ariadna Zybek-Kocik1Aleksandra Klimowicz2Michał Kloska3Dorota Mańkowska-Wierzbicka4Jerzy Sowiński5Marek Ruchała6Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewski Street 49, 60-355 Poznań, PolandWe hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p=0.0001). Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β=0.1014; p=0.003), FT4 (β=0.05412; p=0.048), FT3 (β=0.05242; p=0.038), and TPOAb (β=0.0002; p=0.0025), and the relationships were further confirmed in the multivariate regression analysis.http://dx.doi.org/10.1155/2016/7402469 |
| spellingShingle | Nadia Sawicka-Gutaj Ariadna Zybek-Kocik Aleksandra Klimowicz Michał Kloska Dorota Mańkowska-Wierzbicka Jerzy Sowiński Marek Ruchała Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies International Journal of Endocrinology |
| title | Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies |
| title_full | Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies |
| title_fullStr | Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies |
| title_full_unstemmed | Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies |
| title_short | Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies |
| title_sort | circulating visfatin in hypothyroidism is associated with free thyroid hormones and antithyroperoxidase antibodies |
| url | http://dx.doi.org/10.1155/2016/7402469 |
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