The effects of Gastrodia elata on anxiety-like behavior in mice
The present study investigated the effect of Gastrodia elata extracts (GE) on chronic electric foot-shock stress (cEFS)-induce anxiety-like behaviors in male C57BL/6 mice. Mice were administered GE (200 or 400 mg/kg/day, oral), and then exposed to cEFS (0.6 mA intensity, 1 s every 5 s interval, 3 mi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2373197 |
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| author | Lan-Qiao He Jia-Yu Lin Ming-Zhi Yu Peng-Yu Fan Cen-Jie He Ting-Ting Zhao |
| author_facet | Lan-Qiao He Jia-Yu Lin Ming-Zhi Yu Peng-Yu Fan Cen-Jie He Ting-Ting Zhao |
| author_sort | Lan-Qiao He |
| collection | DOAJ |
| description | The present study investigated the effect of Gastrodia elata extracts (GE) on chronic electric foot-shock stress (cEFS)-induce anxiety-like behaviors in male C57BL/6 mice. Mice were administered GE (200 or 400 mg/kg/day, oral), and then exposed to cEFS (0.6 mA intensity, 1 s every 5 s interval, 3 min duration) for seven days. GE treatment ameliorates the anxiety-like behavior induced by cEFS, which were determined with elevated plus maze test and open field test. cEFS decreased the dopamine and serotonin levels in brain and both were reversed by GE treatment. cEFS increased corticosterone levels in serum and number of c-fos positive cells in brain, which were downregulated by GE treatment. These results suggested that GE ameliorates the anxiety-like behavior by regulating the levels of dopamine and serotonin, the number of c-fos positive cells in the brain, and corticosterone levels in the serum. |
| format | Article |
| id | doaj-art-5600eb36518c4eb38e14516c9ce36816 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-5600eb36518c4eb38e14516c9ce368162025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.23731972373197The effects of Gastrodia elata on anxiety-like behavior in miceLan-Qiao He0Jia-Yu Lin1Ming-Zhi Yu2Peng-Yu Fan3Cen-Jie He4Ting-Ting Zhao5Zhejiang University of TechnologyHangzhou City UniversityHangzhou City UniversityHangzhou City UniversityHangzhou City UniversityHangzhou City UniversityThe present study investigated the effect of Gastrodia elata extracts (GE) on chronic electric foot-shock stress (cEFS)-induce anxiety-like behaviors in male C57BL/6 mice. Mice were administered GE (200 or 400 mg/kg/day, oral), and then exposed to cEFS (0.6 mA intensity, 1 s every 5 s interval, 3 min duration) for seven days. GE treatment ameliorates the anxiety-like behavior induced by cEFS, which were determined with elevated plus maze test and open field test. cEFS decreased the dopamine and serotonin levels in brain and both were reversed by GE treatment. cEFS increased corticosterone levels in serum and number of c-fos positive cells in brain, which were downregulated by GE treatment. These results suggested that GE ameliorates the anxiety-like behavior by regulating the levels of dopamine and serotonin, the number of c-fos positive cells in the brain, and corticosterone levels in the serum.http://dx.doi.org/10.1080/26895293.2024.2373197gastrodia elataneuroprotectionanxietydopamineserotoninc-fos |
| spellingShingle | Lan-Qiao He Jia-Yu Lin Ming-Zhi Yu Peng-Yu Fan Cen-Jie He Ting-Ting Zhao The effects of Gastrodia elata on anxiety-like behavior in mice All Life gastrodia elata neuroprotection anxiety dopamine serotonin c-fos |
| title | The effects of Gastrodia elata on anxiety-like behavior in mice |
| title_full | The effects of Gastrodia elata on anxiety-like behavior in mice |
| title_fullStr | The effects of Gastrodia elata on anxiety-like behavior in mice |
| title_full_unstemmed | The effects of Gastrodia elata on anxiety-like behavior in mice |
| title_short | The effects of Gastrodia elata on anxiety-like behavior in mice |
| title_sort | effects of gastrodia elata on anxiety like behavior in mice |
| topic | gastrodia elata neuroprotection anxiety dopamine serotonin c-fos |
| url | http://dx.doi.org/10.1080/26895293.2024.2373197 |
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