Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

Summary: Isocitrate dehydrogenase (IDH)-mutant gliomas have distinctive metabolic and biological traits that potentially render them susceptible to targeted treatments. Here, by conducting a high-throughput drug screen, we pinpointed a specific vulnerability of IDH-mutant gliomas to zotiraciclib (ZT...

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Main Authors: Ying Pang, Qi Li, Zach Sergi, Guangyang Yu, Olga Kim, Peng Lu, Marina Chan, Xueyu Sang, Herui Wang, Alice Ranjan, Robert W. Robey, Ferri Soheilian, Bao Tran, Felipe J. Núñez, Meili Zhang, Hua Song, Wei Zhang, Dionne Davis, Mark R. Gilbert, Michael M. Gottesman, Zhenggang Liu, Craig J. Thomas, Maria G. Castro, Taranjit S. Gujral, Jing Wu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Therapeutics
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005449
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