A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System
Gemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis. Transient serum enzyme elevations cou...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8812983 |
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| author | Ilenia Mascherona Caterina Maggioli Maira Biggiogero Oreste Mora Lucia Marelli |
| author_facet | Ilenia Mascherona Caterina Maggioli Maira Biggiogero Oreste Mora Lucia Marelli |
| author_sort | Ilenia Mascherona |
| collection | DOAJ |
| description | Gemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis. Transient serum enzyme elevations could be observed during therapy, but clinically significant acute liver injury has been rarely associated with its use. Few cases of acute liver injury have been reported in the literature. We reported the clinical case of a 73--year-old man who developed clinically significant acute hepatic injury after using gemcitabine. Possible causes, clinical presentation, and treatments are discussed. According to the updated RUCAM score, the case was rated 10 points and became a suspected drug-induced liver injury. Moreover, on the liver biopsy, there were histological findings of mild-to-moderate portal hepatitis, eosinophilia, bile duct injury, and mild perisinusoidal fibrosis, suggesting drug damage. |
| format | Article |
| id | doaj-art-55f3381c45f24812bf1d35d973961857 |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-55f3381c45f24812bf1d35d9739618572025-02-03T01:28:08ZengWileyCase Reports in Hepatology2090-65872090-65952020-01-01202010.1155/2020/88129838812983A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring SystemIlenia Mascherona0Caterina Maggioli1Maira Biggiogero2Oreste Mora3Lucia Marelli4Ospedale La Carità, Medicina Interna, Locarno, SwitzerlandAUSL di Bologna, Ospedale di Budrio, Bologna, ItalyClinica Luganese Moncucco, Unità di Ricerca Clinica, Lugano, SwitzerlandClinica Luganese Moncucco, Oncologia Medica, Lugano, SwitzerlandClinica Luganese Moncucco, Oncologia Medica, Lugano, SwitzerlandGemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis. Transient serum enzyme elevations could be observed during therapy, but clinically significant acute liver injury has been rarely associated with its use. Few cases of acute liver injury have been reported in the literature. We reported the clinical case of a 73--year-old man who developed clinically significant acute hepatic injury after using gemcitabine. Possible causes, clinical presentation, and treatments are discussed. According to the updated RUCAM score, the case was rated 10 points and became a suspected drug-induced liver injury. Moreover, on the liver biopsy, there were histological findings of mild-to-moderate portal hepatitis, eosinophilia, bile duct injury, and mild perisinusoidal fibrosis, suggesting drug damage.http://dx.doi.org/10.1155/2020/8812983 |
| spellingShingle | Ilenia Mascherona Caterina Maggioli Maira Biggiogero Oreste Mora Lucia Marelli A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System Case Reports in Hepatology |
| title | A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System |
| title_full | A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System |
| title_fullStr | A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System |
| title_full_unstemmed | A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System |
| title_short | A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System |
| title_sort | severe case of drug induced liver injury after gemcitabine administration a highly probable causality grading as assessed by the updated rucam diagnostic scoring system |
| url | http://dx.doi.org/10.1155/2020/8812983 |
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