Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure
It has been recognized that the sympathetic nervous system is abnormally activated in chronic heart failure, and leads to further worsening chronic heart failure. In the treatment of chronic heart failure many clinical studies have already suggested that the inhibition of the abnormal sympathetic hy...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/847172 |
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| author | Takuya Kishi Yoshitaka Hirooka |
| author_facet | Takuya Kishi Yoshitaka Hirooka |
| author_sort | Takuya Kishi |
| collection | DOAJ |
| description | It has been recognized that the sympathetic nervous system is abnormally activated in chronic heart failure, and leads to further worsening chronic heart failure. In the treatment of chronic heart failure many clinical studies have already suggested that the inhibition of the abnormal sympathetic hyperactivity by beta blockers is beneficial. It has been classically considered that abnormal sympathetic hyperactivity in chronic heart failure is caused by the enhancement of excitatory inputs including changes in peripheral baroreceptor and chemoreceptor reflexes and chemical mediators that control sympathetic outflow. Recently, the abnormalities in the central regulation of sympathetic nerve activity mediated by brain renin angiotensin system-oxidative stress axis and/or proinflammatory cytokines have been focused. Central renin angiotensin system, proinflammatory cytokines, and the interaction between them have been determined as the target of the sympathoinhibitory treatment in experimental animal models with chronic heart failure. In conclusion, we must recognize that chronic heart failure is a syndrome with an abnormal sympathoexcitation, which is caused by the abnormalities in the central regulation of sympathetic nerve activity. |
| format | Article |
| id | doaj-art-55f0d685ec6c4755bbb9e98e0063e494 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-55f0d685ec6c4755bbb9e98e0063e4942025-02-03T01:20:28ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/847172847172Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart FailureTakuya Kishi0Yoshitaka Hirooka1Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, JapanIt has been recognized that the sympathetic nervous system is abnormally activated in chronic heart failure, and leads to further worsening chronic heart failure. In the treatment of chronic heart failure many clinical studies have already suggested that the inhibition of the abnormal sympathetic hyperactivity by beta blockers is beneficial. It has been classically considered that abnormal sympathetic hyperactivity in chronic heart failure is caused by the enhancement of excitatory inputs including changes in peripheral baroreceptor and chemoreceptor reflexes and chemical mediators that control sympathetic outflow. Recently, the abnormalities in the central regulation of sympathetic nerve activity mediated by brain renin angiotensin system-oxidative stress axis and/or proinflammatory cytokines have been focused. Central renin angiotensin system, proinflammatory cytokines, and the interaction between them have been determined as the target of the sympathoinhibitory treatment in experimental animal models with chronic heart failure. In conclusion, we must recognize that chronic heart failure is a syndrome with an abnormal sympathoexcitation, which is caused by the abnormalities in the central regulation of sympathetic nerve activity.http://dx.doi.org/10.1155/2012/847172 |
| spellingShingle | Takuya Kishi Yoshitaka Hirooka Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure Cardiology Research and Practice |
| title | Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure |
| title_full | Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure |
| title_fullStr | Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure |
| title_full_unstemmed | Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure |
| title_short | Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure |
| title_sort | central mechanisms of abnormal sympathoexcitation in chronic heart failure |
| url | http://dx.doi.org/10.1155/2012/847172 |
| work_keys_str_mv | AT takuyakishi centralmechanismsofabnormalsympathoexcitationinchronicheartfailure AT yoshitakahirooka centralmechanismsofabnormalsympathoexcitationinchronicheartfailure |