Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard
Background: Pituitary microadenomas (PMs) are common benign tumors that are often not visualized even when they are present due to their asymptomatic nature. The objective of the study was to evaluate the diagnostic accuracy of non-contrast magnetic resonance imaging (MRI) in the diagnosis of pitui...
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ziauddin University
2025-01-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3421 |
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| author | Sehar Sarfraz Tayyaba Ali Pakeeza Shafiq Zartashia Khan Waqar Azeem Ghazala Rasool Ehsan Ul Haq |
| author_facet | Sehar Sarfraz Tayyaba Ali Pakeeza Shafiq Zartashia Khan Waqar Azeem Ghazala Rasool Ehsan Ul Haq |
| author_sort | Sehar Sarfraz |
| collection | DOAJ |
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Background: Pituitary microadenomas (PMs) are common benign tumors that are often not visualized even when they are present due to their asymptomatic nature. The objective of the study was to evaluate the diagnostic accuracy of non-contrast magnetic resonance imaging (MRI) in the diagnosis of pituitary microadenomas using histopathology as a gold standard.
Methods: This cross-sectional validation study (IRB Approval No. IRB/18/2024/01) included 121 patients presenting with severe headaches and focal brain lesions on CT scans at Doctors Hospital, Lahore from September 2024 to November 2024. In this cross-sectional study, a non-probability consecutive sampling technique was used. A standardized protocol was used for non-contrast MRI and findings were interpreted by experienced radiologists. The comparison was made against histopathology as the reference standard. A 2×2 contingency table was used to calculate sensitivity, specificity, positive predictive value and negative predictive value, and overall diagnostic accuracy by using SPSS version 25.
Results: Of 121 patients (mean age 40.74 ± 10.35 years), 70 (57.9%) were females. Non-contrast MRI showed a sensitivity and specificity of 37.25% (38/102) and 89.47% (17/19) respectively. Specificity is high, meaning that the modality is reliable in eliminating false positives, but sensitivity is low, which means that it won’t find true positives correctly. The percentage of diagnostic accuracy was 45.5% (55/121) which showed that the technique had room for significant improvement.
Conclusion: Pituitary microadenomas can be clinicopathologically screened using non-contrast MRI as an initial radiation-free diagnostic modality with minimal ionizing and contrast agents-based risk being valuable for long-term monitoring.
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| format | Article |
| id | doaj-art-55ec1ce167944af796d6d837bf06ce0c |
| institution | Kabale University |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | ziauddin University |
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| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-55ec1ce167944af796d6d837bf06ce0c2025-01-19T20:18:26Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-01-0114110.36283/ziun-pjmd14-1/012Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold StandardSehar Sarfraz0Tayyaba Ali1Pakeeza Shafiq2Zartashia Khan3Waqar Azeem4 Ghazala Rasool5Ehsan Ul Haq6Doctors Hospital and Medical Centre, Lahore, Pakistan.Islamabad Diagnostic Centre, Islamabad, PakistanNorthern Border University, Arar, Saudi Arabia, KSA Al Khalid Hospital, Rahim yar khan, PakistanIsra University, Hyderabad, PakistanNorthern Border University, Arar, Saudi Arabia, KSAFree University of Berlin, Germany. Background: Pituitary microadenomas (PMs) are common benign tumors that are often not visualized even when they are present due to their asymptomatic nature. The objective of the study was to evaluate the diagnostic accuracy of non-contrast magnetic resonance imaging (MRI) in the diagnosis of pituitary microadenomas using histopathology as a gold standard. Methods: This cross-sectional validation study (IRB Approval No. IRB/18/2024/01) included 121 patients presenting with severe headaches and focal brain lesions on CT scans at Doctors Hospital, Lahore from September 2024 to November 2024. In this cross-sectional study, a non-probability consecutive sampling technique was used. A standardized protocol was used for non-contrast MRI and findings were interpreted by experienced radiologists. The comparison was made against histopathology as the reference standard. A 2×2 contingency table was used to calculate sensitivity, specificity, positive predictive value and negative predictive value, and overall diagnostic accuracy by using SPSS version 25. Results: Of 121 patients (mean age 40.74 ± 10.35 years), 70 (57.9%) were females. Non-contrast MRI showed a sensitivity and specificity of 37.25% (38/102) and 89.47% (17/19) respectively. Specificity is high, meaning that the modality is reliable in eliminating false positives, but sensitivity is low, which means that it won’t find true positives correctly. The percentage of diagnostic accuracy was 45.5% (55/121) which showed that the technique had room for significant improvement. Conclusion: Pituitary microadenomas can be clinicopathologically screened using non-contrast MRI as an initial radiation-free diagnostic modality with minimal ionizing and contrast agents-based risk being valuable for long-term monitoring. https://ojs.zu.edu.pk/pjmd/article/view/3421Pituitary MicroadenomaNon-Contrast MRIHistopathologyEndocrine Tumors |
| spellingShingle | Sehar Sarfraz Tayyaba Ali Pakeeza Shafiq Zartashia Khan Waqar Azeem Ghazala Rasool Ehsan Ul Haq Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard Pakistan Journal of Medicine and Dentistry Pituitary Microadenoma Non-Contrast MRI Histopathology Endocrine Tumors |
| title | Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard |
| title_full | Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard |
| title_fullStr | Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard |
| title_full_unstemmed | Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard |
| title_short | Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard |
| title_sort | diagnostic accuracy of non contrast magnetic resonance imaging in diagnosing pituitary micro adenoma taking histopathology as gold standard |
| topic | Pituitary Microadenoma Non-Contrast MRI Histopathology Endocrine Tumors |
| url | https://ojs.zu.edu.pk/pjmd/article/view/3421 |
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