Association of clinical-morphological and molecular-genetic factors (mutations in <i>GNAQ</i> and <i>GNA11</i> oncogenes and <i>АBСB1</i> gene polymorphism) in patients with iris melanoma

Association of clinical-morphological and molecular-genetic factors (mutations in <i>GNAQ</i> and <i>GNA11</i> oncogenes and <i>АBСB1</i> gene polymorphism) in patients with iris melanoma

Purpose: to analyze the frequency of GNAQ/GNA11 mutations in circulating tumor DNA and tumor tissue, and the frequency of genotypes of polymorphic marker C3435T of ABCB1 gene in patients with iris melanoma. Material and methods. The study included 139 patients with uveal melanoma (UM) followed in 20...

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Bibliographic Details
Main Authors: S. V. Saakyan, I. V. Svirina, A. Yu. Tsygankov, A. M. Burdennyi, V. I. Loginov
Format: Article
Language:Russian
Published: Real Time Ltd 2024-10-01
Series:Российский офтальмологический журнал
Subjects:
uveal melanoma
iris melanoma
choroidal melanoma
ctdna
<i>gnaq</i>
<i>gna11</i>
<i>аbсb1</i>
Online Access:https://roj.igb.ru/jour/article/view/1549
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