Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease
Hepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC) (n=65), chola...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/402394 |
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| author | Jerzy Kaczynski Göran Hansson Sven Wallerstedt |
| author_facet | Jerzy Kaczynski Göran Hansson Sven Wallerstedt |
| author_sort | Jerzy Kaczynski |
| collection | DOAJ |
| description | Hepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC) (n=65), cholangiocellular carcinoma (n=3), or suspected PLC, which turned out to be metastases (n=18)
or a benign disorder (n=11). None of the patients had a family history of porphyry or clinical signs of porphyry. Increased aminolevulinic acid or porphyrin values were common not only in patients with PLC (43%) but also in metastatic (50%) and benign (64%) liver disorders. The corresponding proportion for HCC patients with liver cirrhosis (55%) was higher (P<.05)
than in those without cirrhosis (17%). We conclude that symptomatic porphyries are unusual in PLC, whereas elevated urinary and/or faecal porphyrins are common, primarily reflecting a parallel liver disease and not the PLC. |
| format | Article |
| id | doaj-art-55d80b587d4d4096b713497149352748 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-55d80b587d4d4096b7134971493527482025-02-03T05:46:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/402394402394Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver DiseaseJerzy Kaczynski0Göran Hansson1Sven Wallerstedt2Department of Medicine, Göteborg University, Sahlgren's University Hospital, SE-41685 Göteborg, SwedenDepartment of Pathology, Göteborg University, Sahlgren's University Hospital, SE-41345 Göteborg, SwedenDepartment of Medicine, Göteborg University, Sahlgren's University Hospital, SE-41685 Göteborg, SwedenHepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC) (n=65), cholangiocellular carcinoma (n=3), or suspected PLC, which turned out to be metastases (n=18) or a benign disorder (n=11). None of the patients had a family history of porphyry or clinical signs of porphyry. Increased aminolevulinic acid or porphyrin values were common not only in patients with PLC (43%) but also in metastatic (50%) and benign (64%) liver disorders. The corresponding proportion for HCC patients with liver cirrhosis (55%) was higher (P<.05) than in those without cirrhosis (17%). We conclude that symptomatic porphyries are unusual in PLC, whereas elevated urinary and/or faecal porphyrins are common, primarily reflecting a parallel liver disease and not the PLC.http://dx.doi.org/10.1155/2009/402394 |
| spellingShingle | Jerzy Kaczynski Göran Hansson Sven Wallerstedt Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease Gastroenterology Research and Practice |
| title | Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease |
| title_full | Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease |
| title_fullStr | Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease |
| title_full_unstemmed | Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease |
| title_short | Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease |
| title_sort | increased porphyrins in primary liver cancer mainly reflect a parallel liver disease |
| url | http://dx.doi.org/10.1155/2009/402394 |
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