Risk of TB disease in individuals with cancer
BACKGROUND: Cancer increases the risk of developing TB disease; however, there are limited data on the magnitude of risk by cancer type and timing after diagnosis of cancer in low TB incidence settings. METHODS: We conducted a nested case-control study of persons in Quebec between 1993 and 2017, inc...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2025-01-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00009 |
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| author | T. Diefenbach-Elstob S. Tabrizi P. Rivest A. Benedetti L. Azoulay K. Schwartzman C. Greenaway |
| author_facet | T. Diefenbach-Elstob S. Tabrizi P. Rivest A. Benedetti L. Azoulay K. Schwartzman C. Greenaway |
| author_sort | T. Diefenbach-Elstob |
| collection | DOAJ |
| description | BACKGROUND: Cancer increases the risk of developing TB disease; however, there are limited data on the magnitude of risk by cancer type and timing after diagnosis of cancer in low TB incidence settings. METHODS: We conducted a nested case-control study of persons in Quebec between 1993 and 2017, including people with TB disease and matched controls. Conditional logistic regression was used to estimate adjusted odds ratios (aORs) of developing TB among people with cancer overall, by sub-type, and by time from cancer to TB diagnosis. RESULTS: There were 4,283 people with TB disease and 268,420 matched controls. The median age for people with TB disease and controls was respectively 46 years (IQR 30–67) and 36 years (24–47). Prior exposure to cancer was associated with TB disease (aOR 6.3, 95% CI 5.3–7.6). The risk of TB diagnosis was highest within 3 months of cancer diagnosis (aOR 26.6, 95% CI 19.6–36.2), with 60% of diagnoses of TB disease occurring within 6 months of cancer diagnosis. CONCLUSION: Risk of TB varies over time and by cancer type. Screening and treatment should be considered for potentially preventable TB (diagnosed more than 6 months post-cancer), particularly in those with respiratory, haematologic, and head and neck cancers. |
| format | Article |
| id | doaj-art-55d152029b85464d80961782f95dca7a |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-55d152029b85464d80961782f95dca7a2025-01-23T13:39:30ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902025-01-0121455210.5588/ijtldopen.24.04409Risk of TB disease in individuals with cancerT. Diefenbach-Elstob0S. Tabrizi1P. Rivest2A. Benedetti3L. Azoulay4K. Schwartzman5C. Greenaway6Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada;Department of Medicine, McGill University, Montreal, QC, Canada;Département de médicine sociale et préventive, École de santé publique de l'Université de Montréal, Montréal, QC, Canada;Department of Medicine, McGill University, Montreal, QC, Canada;Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada;Respiratory Division, Department of Medicine, McGill University, Montreal, QC, Canada;Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada;BACKGROUND: Cancer increases the risk of developing TB disease; however, there are limited data on the magnitude of risk by cancer type and timing after diagnosis of cancer in low TB incidence settings. METHODS: We conducted a nested case-control study of persons in Quebec between 1993 and 2017, including people with TB disease and matched controls. Conditional logistic regression was used to estimate adjusted odds ratios (aORs) of developing TB among people with cancer overall, by sub-type, and by time from cancer to TB diagnosis. RESULTS: There were 4,283 people with TB disease and 268,420 matched controls. The median age for people with TB disease and controls was respectively 46 years (IQR 30–67) and 36 years (24–47). Prior exposure to cancer was associated with TB disease (aOR 6.3, 95% CI 5.3–7.6). The risk of TB diagnosis was highest within 3 months of cancer diagnosis (aOR 26.6, 95% CI 19.6–36.2), with 60% of diagnoses of TB disease occurring within 6 months of cancer diagnosis. CONCLUSION: Risk of TB varies over time and by cancer type. Screening and treatment should be considered for potentially preventable TB (diagnosed more than 6 months post-cancer), particularly in those with respiratory, haematologic, and head and neck cancers.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00009reactivationmalignancyscreening |
| spellingShingle | T. Diefenbach-Elstob S. Tabrizi P. Rivest A. Benedetti L. Azoulay K. Schwartzman C. Greenaway Risk of TB disease in individuals with cancer IJTLD Open reactivation malignancy screening |
| title | Risk of TB disease in individuals with cancer |
| title_full | Risk of TB disease in individuals with cancer |
| title_fullStr | Risk of TB disease in individuals with cancer |
| title_full_unstemmed | Risk of TB disease in individuals with cancer |
| title_short | Risk of TB disease in individuals with cancer |
| title_sort | risk of tb disease in individuals with cancer |
| topic | reactivation malignancy screening |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00009 |
| work_keys_str_mv | AT tdiefenbachelstob riskoftbdiseaseinindividualswithcancer AT stabrizi riskoftbdiseaseinindividualswithcancer AT privest riskoftbdiseaseinindividualswithcancer AT abenedetti riskoftbdiseaseinindividualswithcancer AT lazoulay riskoftbdiseaseinindividualswithcancer AT kschwartzman riskoftbdiseaseinindividualswithcancer AT cgreenaway riskoftbdiseaseinindividualswithcancer |