Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study
ABSTRACT Background and Purpose Observational studies have indicated a high occurrence of coexistence between myasthenia gravis (MG) and autoimmune thyroid disease (AITD) in clinical settings, but the causal relationship between the two conditions remains ambiguous. Therefore, this study endeavors t...
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70235 |
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| author | Yao Wang Ke Wang Jing Lu Peng Xu Dongmei Zhang Xinzhi Chen Jian Wang |
| author_facet | Yao Wang Ke Wang Jing Lu Peng Xu Dongmei Zhang Xinzhi Chen Jian Wang |
| author_sort | Yao Wang |
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| description | ABSTRACT Background and Purpose Observational studies have indicated a high occurrence of coexistence between myasthenia gravis (MG) and autoimmune thyroid disease (AITD) in clinical settings, but the causal relationship between the two conditions remains ambiguous. Therefore, this study endeavors to investigate the causal links between MG, along with its subgroups, and AITD through a Mendelian randomization (MR) approach. Methods Genetic instrumental variables associated with MG and AITD were selected from three major publicly available GWAS databases for MR analysis. The primary method for evaluating causal effects was the inverse variance weighted (IVW) method. Supplementary methods included MR‐Egger regression and weighted median. The reliability and stability of the results were ensured through tests for heterogeneity, assessment of pleiotropy, and sensitivity analysis using the leave‐one‐out approach. Results The investigation revealed reciprocal causal associations between MG and both Graves’ disease and autoimmune hypothyroidism. Genetic predisposition to MG was linked to an increased likelihood of developing Hashimoto's thyroiditis (OR = 1.242(1.073–1.437, P = 0.0036)), and early‐onset MG also exhibited an association with an elevated risk of HT (OR = 1.157(1.073‐1.246), P = 1.269×10−4). No statistically significant relationships were found for the other conditions. Conclusion This extensive MR analysis provides evidence suggesting a potential association between MG and AITD, particularly with Graves' disease and Hashimoto's thyroiditis. Consequently, proactive treatment strategies targeting either MG or autoimmune thyroid disorders may help mitigate the risk of comorbidities in affected patients. |
| format | Article |
| id | doaj-art-55cd1c604edf4e3183567f13f4f072d7 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-55cd1c604edf4e3183567f13f4f072d72025-01-29T13:36:40ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70235Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization StudyYao Wang0Ke Wang1Jing Lu2Peng Xu3Dongmei Zhang4Xinzhi Chen5Jian Wang6College of Traditional Chinese Medicine Changchun University of Chinese Medicine Changchun ChinaCollege of Traditional Chinese Medicine Changchun University of Chinese Medicine Changchun ChinaResearch Center of Traditional Chinese Medicine The Affiliated Hospital to Changchun University of Chinese Medicine Changchun ChinaDepartment of Neurology The Affiliated Hospital to Changchun University of Chinese Medicine Changchun ChinaScientific Research Office The Affiliated Hospital to Changchun University of Chinese Medicine Changchun ChinaDepartment of Neurology The First Clinical Hospital Research Institute of Jilin Academy of ChineseMedicine Changchun ChinaDepartment of Neurology The Affiliated Hospital to Changchun University of Chinese Medicine Changchun ChinaABSTRACT Background and Purpose Observational studies have indicated a high occurrence of coexistence between myasthenia gravis (MG) and autoimmune thyroid disease (AITD) in clinical settings, but the causal relationship between the two conditions remains ambiguous. Therefore, this study endeavors to investigate the causal links between MG, along with its subgroups, and AITD through a Mendelian randomization (MR) approach. Methods Genetic instrumental variables associated with MG and AITD were selected from three major publicly available GWAS databases for MR analysis. The primary method for evaluating causal effects was the inverse variance weighted (IVW) method. Supplementary methods included MR‐Egger regression and weighted median. The reliability and stability of the results were ensured through tests for heterogeneity, assessment of pleiotropy, and sensitivity analysis using the leave‐one‐out approach. Results The investigation revealed reciprocal causal associations between MG and both Graves’ disease and autoimmune hypothyroidism. Genetic predisposition to MG was linked to an increased likelihood of developing Hashimoto's thyroiditis (OR = 1.242(1.073–1.437, P = 0.0036)), and early‐onset MG also exhibited an association with an elevated risk of HT (OR = 1.157(1.073‐1.246), P = 1.269×10−4). No statistically significant relationships were found for the other conditions. Conclusion This extensive MR analysis provides evidence suggesting a potential association between MG and AITD, particularly with Graves' disease and Hashimoto's thyroiditis. Consequently, proactive treatment strategies targeting either MG or autoimmune thyroid disorders may help mitigate the risk of comorbidities in affected patients.https://doi.org/10.1002/brb3.70235autoimmune thyroid disease | causation | genetics | Mendelian randomness | myasthenia gravis |
| spellingShingle | Yao Wang Ke Wang Jing Lu Peng Xu Dongmei Zhang Xinzhi Chen Jian Wang Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study Brain and Behavior autoimmune thyroid disease | causation | genetics | Mendelian randomness | myasthenia gravis |
| title | Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study |
| title_full | Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study |
| title_fullStr | Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study |
| title_full_unstemmed | Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study |
| title_short | Association of Myasthenia Gravis With Autoimmune Thyroid Disease: A Bidirectional Mendelian Randomization Study |
| title_sort | association of myasthenia gravis with autoimmune thyroid disease a bidirectional mendelian randomization study |
| topic | autoimmune thyroid disease | causation | genetics | Mendelian randomness | myasthenia gravis |
| url | https://doi.org/10.1002/brb3.70235 |
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