Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia.
<h4>Background</h4>Impaired growth among infants remains one of the leading nutrition problems globally. In this study, we aimed to compare the growth trajectory rate and evaluate growth trajectory characteristics among children, who are HIV exposed uninfected (HEU) and HIV unexposed uni...
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Public Library of Science (PLoS)
2021-01-01
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| author | Obvious Nchimunya Chilyabanyama Roma Chilengi Natasha Makabilo Laban Masuzyo Chirwa Michelo Simunyandi Luiza Miyanda Hatyoka Innocent Ngaruye Najeeha Talat Iqbal Samuel Bosomprah |
| author_facet | Obvious Nchimunya Chilyabanyama Roma Chilengi Natasha Makabilo Laban Masuzyo Chirwa Michelo Simunyandi Luiza Miyanda Hatyoka Innocent Ngaruye Najeeha Talat Iqbal Samuel Bosomprah |
| author_sort | Obvious Nchimunya Chilyabanyama |
| collection | DOAJ |
| description | <h4>Background</h4>Impaired growth among infants remains one of the leading nutrition problems globally. In this study, we aimed to compare the growth trajectory rate and evaluate growth trajectory characteristics among children, who are HIV exposed uninfected (HEU) and HIV unexposed uninfected (HUU), under two years in Zambia.<h4>Method</h4>Our study used data from the ROVAS II study (PACTR201804003096919), an open-label randomized control trial of two verses three doses of live, attenuated, oral RotarixTM administered 6 &10 weeks or at 6 &10 weeks plus an additional dose at 9 months of age, conducted at George clinic in Lusaka, Zambia. Anthropometric measurements (height and weight) were collected on all scheduled and unscheduled visits. We defined linear growth velocity as the rate of change in height and estimated linear growth velocity as the first derivative of the mixed effect model with fractional polynomial transformations and, thereafter, used the second derivative test to determine the peak height and age at peak heigh.<h4>Results</h4>We included 212 infants in this study with median age 6 (IQR: 6-6) weeks of age. Of these 97 (45.3%) were female, 35 (16.4%) were stunted, and 59 (27.6%) were exposed to HIV at baseline. Growth velocity was consistently below the 3rd percentile of the WHO linear growth standard for HEU and HUU children. The peak height and age at peak height among HEU children were 74.7 cm (95% CI = 73.9-75.5) and 15.5 months (95% CI = 14.7-16.3) respectively and those for HUU were 73 cm (95% CI = 72.1-74.0) and 15.6 months (95% CI = 14.5-16.6) respectively.<h4>Conclusion</h4>We found no difference in growth trajectories between infants who are HEU and HUU. However, the data suggests that poor linear growth is universal and profound in this cohort and may have already occurred in utero. |
| format | Article |
| id | doaj-art-55c585fddc20439db1140d79b997b6d3 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-55c585fddc20439db1140d79b997b6d32025-01-18T05:31:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025644310.1371/journal.pone.0256443Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia.Obvious Nchimunya ChilyabanyamaRoma ChilengiNatasha Makabilo LabanMasuzyo ChirwaMichelo SimunyandiLuiza Miyanda HatyokaInnocent NgaruyeNajeeha Talat IqbalSamuel Bosomprah<h4>Background</h4>Impaired growth among infants remains one of the leading nutrition problems globally. In this study, we aimed to compare the growth trajectory rate and evaluate growth trajectory characteristics among children, who are HIV exposed uninfected (HEU) and HIV unexposed uninfected (HUU), under two years in Zambia.<h4>Method</h4>Our study used data from the ROVAS II study (PACTR201804003096919), an open-label randomized control trial of two verses three doses of live, attenuated, oral RotarixTM administered 6 &10 weeks or at 6 &10 weeks plus an additional dose at 9 months of age, conducted at George clinic in Lusaka, Zambia. Anthropometric measurements (height and weight) were collected on all scheduled and unscheduled visits. We defined linear growth velocity as the rate of change in height and estimated linear growth velocity as the first derivative of the mixed effect model with fractional polynomial transformations and, thereafter, used the second derivative test to determine the peak height and age at peak heigh.<h4>Results</h4>We included 212 infants in this study with median age 6 (IQR: 6-6) weeks of age. Of these 97 (45.3%) were female, 35 (16.4%) were stunted, and 59 (27.6%) were exposed to HIV at baseline. Growth velocity was consistently below the 3rd percentile of the WHO linear growth standard for HEU and HUU children. The peak height and age at peak height among HEU children were 74.7 cm (95% CI = 73.9-75.5) and 15.5 months (95% CI = 14.7-16.3) respectively and those for HUU were 73 cm (95% CI = 72.1-74.0) and 15.6 months (95% CI = 14.5-16.6) respectively.<h4>Conclusion</h4>We found no difference in growth trajectories between infants who are HEU and HUU. However, the data suggests that poor linear growth is universal and profound in this cohort and may have already occurred in utero.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0256443&type=printable |
| spellingShingle | Obvious Nchimunya Chilyabanyama Roma Chilengi Natasha Makabilo Laban Masuzyo Chirwa Michelo Simunyandi Luiza Miyanda Hatyoka Innocent Ngaruye Najeeha Talat Iqbal Samuel Bosomprah Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. PLoS ONE |
| title | Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. |
| title_full | Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. |
| title_fullStr | Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. |
| title_full_unstemmed | Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. |
| title_short | Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. |
| title_sort | comparing growth velocity of hiv exposed and non exposed infants an observational study of infants enrolled in a randomized control trial in zambia |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0256443&type=printable |
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