Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease
Until the cause(s) of inflammatory bowel disease are identified, improvements in therapy will likely come from improved anti-inflammatory therapy or improved drug delivery systems. There are many potential targets for anti-inflammatory therapy, including the synthesis of specific inflammatory mediat...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1994/765272 |
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| _version_ | 1832548394350936064 |
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| author | John L Wallace |
| author_facet | John L Wallace |
| author_sort | John L Wallace |
| collection | DOAJ |
| description | Until the cause(s) of inflammatory bowel disease are identified, improvements in therapy will likely come from improved anti-inflammatory therapy or improved drug delivery systems. There are many potential targets for anti-inflammatory therapy, including the synthesis of specific inflammatory mediators. This review focuses on the potential for developing therapy aimed at three targets: nerves and neuropeptides; coagulation and thrombosis; and adhesion molecules. In each case, evidence is presented from clinical and/or experimental studies that supports the hypothesis that these are rational targets for anti-inflammatory drug development. |
| format | Article |
| id | doaj-art-55bc8f4bb6f34a5b9690be82ab8311ad |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-55bc8f4bb6f34a5b9690be82ab8311ad2025-02-03T06:14:12ZengWileyCanadian Journal of Gastroenterology0835-79001994-01-018637337810.1155/1994/765272Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel DiseaseJohn L Wallace0Intestinal Diseases Research Group, University of Calgary, Calgary, Alberta, CanadaUntil the cause(s) of inflammatory bowel disease are identified, improvements in therapy will likely come from improved anti-inflammatory therapy or improved drug delivery systems. There are many potential targets for anti-inflammatory therapy, including the synthesis of specific inflammatory mediators. This review focuses on the potential for developing therapy aimed at three targets: nerves and neuropeptides; coagulation and thrombosis; and adhesion molecules. In each case, evidence is presented from clinical and/or experimental studies that supports the hypothesis that these are rational targets for anti-inflammatory drug development.http://dx.doi.org/10.1155/1994/765272 |
| spellingShingle | John L Wallace Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease Canadian Journal of Gastroenterology |
| title | Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease |
| title_full | Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease |
| title_fullStr | Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease |
| title_full_unstemmed | Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease |
| title_short | Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease |
| title_sort | novel targets for anti inflammatory therapy in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/1994/765272 |
| work_keys_str_mv | AT johnlwallace noveltargetsforantiinflammatorytherapyininflammatoryboweldisease |