The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment
HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. To date, there have been no pan-cancer studies of HNRNPA2B1, particularly within the TME. Therefore, we conducted a pan-cancer anal...
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Wiley
2024-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/5515307 |
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| author | Tao Huang Gang Zhu Fan Chen |
| author_facet | Tao Huang Gang Zhu Fan Chen |
| author_sort | Tao Huang |
| collection | DOAJ |
| description | HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. To date, there have been no pan-cancer studies of HNRNPA2B1, particularly within the TME. Therefore, we conducted a pan-cancer analysis of HNRNPA2B1 using TCGA data. Based on datasets from TCGA, TARGET, Genotype-Tissue Expression, and Human Protein Atlas, we employed a range of bioinformatics approaches to explore the potential oncogenic role of HNRNPA2B1. This included analyzing the association of HNRNPA2B1 expression with prognosis, tumor mutation burden (TMB), microsatellite instability (MSI), immune response, and immune cell infiltration of individual tumors. We further validated the bioinformatic findings using immunohistochemistry techniques. HNRNPA2B1 was found to be differentially expressed across most tumor types in TCGA’s pan-cancer database and was predictive of poorer clinical staging and survival status. HNRNPA2B1 expression was also closely linked to TMB, MSI, tumor stemness, and chemotherapy response. HNRNPA2B1 plays a significant role in the TME and is involved in the regulation of novel immunotherapies. Its expression is significantly associated with the infiltration of macrophages, dendritic cells, NK cells, and T cells. Furthermore, HNRNPA2B1 is closely associated with immune checkpoints, immune-stimulatory genes, immune-inhibitory genes, MHC genes, chemokines, and chemokine receptors. We performed a comprehensive evaluation of HNRNPA2B1, revealing its potential role as a prognostic indicator for patients and its immunomodulatory functions. |
| format | Article |
| id | doaj-art-55b0946a917642438a2166ce376f00a7 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-55b0946a917642438a2166ce376f00a72025-02-03T10:46:38ZengWileyJournal of Immunology Research2314-71562024-01-01202410.1155/2024/5515307The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune MicroenvironmentTao Huang0Gang Zhu1Fan Chen2Department of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryHNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. To date, there have been no pan-cancer studies of HNRNPA2B1, particularly within the TME. Therefore, we conducted a pan-cancer analysis of HNRNPA2B1 using TCGA data. Based on datasets from TCGA, TARGET, Genotype-Tissue Expression, and Human Protein Atlas, we employed a range of bioinformatics approaches to explore the potential oncogenic role of HNRNPA2B1. This included analyzing the association of HNRNPA2B1 expression with prognosis, tumor mutation burden (TMB), microsatellite instability (MSI), immune response, and immune cell infiltration of individual tumors. We further validated the bioinformatic findings using immunohistochemistry techniques. HNRNPA2B1 was found to be differentially expressed across most tumor types in TCGA’s pan-cancer database and was predictive of poorer clinical staging and survival status. HNRNPA2B1 expression was also closely linked to TMB, MSI, tumor stemness, and chemotherapy response. HNRNPA2B1 plays a significant role in the TME and is involved in the regulation of novel immunotherapies. Its expression is significantly associated with the infiltration of macrophages, dendritic cells, NK cells, and T cells. Furthermore, HNRNPA2B1 is closely associated with immune checkpoints, immune-stimulatory genes, immune-inhibitory genes, MHC genes, chemokines, and chemokine receptors. We performed a comprehensive evaluation of HNRNPA2B1, revealing its potential role as a prognostic indicator for patients and its immunomodulatory functions.http://dx.doi.org/10.1155/2024/5515307 |
| spellingShingle | Tao Huang Gang Zhu Fan Chen The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment Journal of Immunology Research |
| title | The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment |
| title_full | The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment |
| title_fullStr | The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment |
| title_full_unstemmed | The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment |
| title_short | The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment |
| title_sort | potential impact of hnrnpa2b1 on human cancers prognosis and immune microenvironment |
| url | http://dx.doi.org/10.1155/2024/5515307 |
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