Successful Treatment of Cisplatin Overdose with Plasma Exchange
Accidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent. However, the optimal strategy to treat such patients remains to be established. Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/802312 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549997167509504 |
|---|---|
| author | Yasuhiro Yamada Yoshiaki Ikuta Kisato Nosaka Nobutomo Miyanari Naoko Hayashi Hiroaki Mitsuya Hideo Baba |
| author_facet | Yasuhiro Yamada Yoshiaki Ikuta Kisato Nosaka Nobutomo Miyanari Naoko Hayashi Hiroaki Mitsuya Hideo Baba |
| author_sort | Yasuhiro Yamada |
| collection | DOAJ |
| description | Accidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent. However, the optimal strategy to treat such patients remains to be established. Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous hydration, granulocyte colony-stimulating factor (G-CSF) administration, and other supportive care. A 67-year-old man with esophageal carcinoma received a large cisplatin overdose of 240 mg/m2, when he received adjuvant therapy following subtotal esophagectomy. On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. With 7 cycles of plasma exchange, the cisplatin concentration decreased from 2,350 to 110 ng/mL. Severe bone marrow suppression with high fever ensued on day 10, which was successfully treated with G-CSF and antibiotics. Despite moderate hearing sense reduction, he recovered without significant complications. Immediate plasma exchange with hydration and other care was efficacious in quickly lowering cisplatin concentrations. |
| format | Article |
| id | doaj-art-55af656dea0c4e89a8cb5a35002763bf |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-55af656dea0c4e89a8cb5a35002763bf2025-02-03T06:08:02ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/802312802312Successful Treatment of Cisplatin Overdose with Plasma ExchangeYasuhiro Yamada0Yoshiaki Ikuta1Kisato Nosaka2Nobutomo Miyanari3Naoko Hayashi4Hiroaki Mitsuya5Hideo Baba6Department of Hematology & Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Hematology & Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Hematology & Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Kumamoto University School of Medicine, Kumamoto 860-8556, JapanAccidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent. However, the optimal strategy to treat such patients remains to be established. Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous hydration, granulocyte colony-stimulating factor (G-CSF) administration, and other supportive care. A 67-year-old man with esophageal carcinoma received a large cisplatin overdose of 240 mg/m2, when he received adjuvant therapy following subtotal esophagectomy. On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. With 7 cycles of plasma exchange, the cisplatin concentration decreased from 2,350 to 110 ng/mL. Severe bone marrow suppression with high fever ensued on day 10, which was successfully treated with G-CSF and antibiotics. Despite moderate hearing sense reduction, he recovered without significant complications. Immediate plasma exchange with hydration and other care was efficacious in quickly lowering cisplatin concentrations.http://dx.doi.org/10.1155/2010/802312 |
| spellingShingle | Yasuhiro Yamada Yoshiaki Ikuta Kisato Nosaka Nobutomo Miyanari Naoko Hayashi Hiroaki Mitsuya Hideo Baba Successful Treatment of Cisplatin Overdose with Plasma Exchange Case Reports in Medicine |
| title | Successful Treatment of Cisplatin Overdose with Plasma Exchange |
| title_full | Successful Treatment of Cisplatin Overdose with Plasma Exchange |
| title_fullStr | Successful Treatment of Cisplatin Overdose with Plasma Exchange |
| title_full_unstemmed | Successful Treatment of Cisplatin Overdose with Plasma Exchange |
| title_short | Successful Treatment of Cisplatin Overdose with Plasma Exchange |
| title_sort | successful treatment of cisplatin overdose with plasma exchange |
| url | http://dx.doi.org/10.1155/2010/802312 |
| work_keys_str_mv | AT yasuhiroyamada successfultreatmentofcisplatinoverdosewithplasmaexchange AT yoshiakiikuta successfultreatmentofcisplatinoverdosewithplasmaexchange AT kisatonosaka successfultreatmentofcisplatinoverdosewithplasmaexchange AT nobutomomiyanari successfultreatmentofcisplatinoverdosewithplasmaexchange AT naokohayashi successfultreatmentofcisplatinoverdosewithplasmaexchange AT hiroakimitsuya successfultreatmentofcisplatinoverdosewithplasmaexchange AT hideobaba successfultreatmentofcisplatinoverdosewithplasmaexchange |