Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy
Dyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK9 in diabetic peripheral neuropathy is still unclear. In this...
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The Japan Endocrine Society
2024-03-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0359/_html/-char/en |
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| author | Na Cui Yonghao Feng Ming Wang Xiuyan Lu Yongmei Huang Yinghui Chen Xiaohong Shi |
| author_facet | Na Cui Yonghao Feng Ming Wang Xiuyan Lu Yongmei Huang Yinghui Chen Xiaohong Shi |
| author_sort | Na Cui |
| collection | DOAJ |
| description | Dyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK9 in diabetic peripheral neuropathy is still unclear. In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral neuropathy and its underlying mechanisms were investigated. The diabetic peripheral neuropathy rat model was established by using a high-fat diet combined with streptozotocin injection, and experimental subjects were divided into normal, diabetic peripheral neuropathy, and alirocumab groups. The results showed that Alirocumab improved nerve conduction, morphological changes, and small fiber deficits in rats with DPN, possibly related to its amelioration of oxidative stress and the inflammatory response. |
| format | Article |
| id | doaj-art-55a8a7cbaf34444cb7d571f5cd7e5e76 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-55a8a7cbaf34444cb7d571f5cd7e5e762025-01-22T06:35:05ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-03-0171323324410.1507/endocrj.EJ23-0359endocrjProtective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathyNa Cui0Yonghao Feng1Ming Wang2Xiuyan Lu3Yongmei Huang4Yinghui Chen5Xiaohong Shi6Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. ChinaDepartment of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. ChinaDepartment of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. ChinaDepartment of Electromyography, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. ChinaDepartment of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. ChinaDyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK9 in diabetic peripheral neuropathy is still unclear. In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral neuropathy and its underlying mechanisms were investigated. The diabetic peripheral neuropathy rat model was established by using a high-fat diet combined with streptozotocin injection, and experimental subjects were divided into normal, diabetic peripheral neuropathy, and alirocumab groups. The results showed that Alirocumab improved nerve conduction, morphological changes, and small fiber deficits in rats with DPN, possibly related to its amelioration of oxidative stress and the inflammatory response.https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0359/_html/-char/endiabetic peripheral neuropathyalirocumabsciatic nerveoxidative stressinflammatory response |
| spellingShingle | Na Cui Yonghao Feng Ming Wang Xiuyan Lu Yongmei Huang Yinghui Chen Xiaohong Shi Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy Endocrine Journal diabetic peripheral neuropathy alirocumab sciatic nerve oxidative stress inflammatory response |
| title | Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy |
| title_full | Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy |
| title_fullStr | Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy |
| title_full_unstemmed | Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy |
| title_short | Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy |
| title_sort | protective effect of alirocumab a pcsk9 inhibitor on the sciatic nerve of rats with diabetic peripheral neuropathy |
| topic | diabetic peripheral neuropathy alirocumab sciatic nerve oxidative stress inflammatory response |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0359/_html/-char/en |
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