NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy

NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy

Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes. Methods. NADPH oxidase was localised using Western...

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Bibliographic Details
Main Authors: Nik M. Mustapha, Joanna M. Tarr, Eva M. Kohner, Rakesh Chibber
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Ophthalmology
Online Access:http://dx.doi.org/10.1155/2010/746978
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