Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study
Introduction. In non-metastatic breast cancer patients, the REMAGUS02 neoadjuvant study was the first to report a significant impact of circulating tumor cells (CTCs) detection by the CellSearch system on the distant metastasis-free survival (DMFS) and overall survival (OS) endpoints. However, these...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/130470 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560730903150592 |
|---|---|
| author | François-Clément Bidard Lisa Belin Suzette Delaloge Florence Lerebours Charlotte Ngo Fabien Reyal Séverine Alran Sylvie Giacchetti Michel Marty Ronald Lebofsky Jean-Yves Pierga |
| author_facet | François-Clément Bidard Lisa Belin Suzette Delaloge Florence Lerebours Charlotte Ngo Fabien Reyal Séverine Alran Sylvie Giacchetti Michel Marty Ronald Lebofsky Jean-Yves Pierga |
| author_sort | François-Clément Bidard |
| collection | DOAJ |
| description | Introduction. In non-metastatic breast cancer patients, the REMAGUS02 neoadjuvant study was the first to report a significant impact of circulating tumor cells (CTCs) detection by the CellSearch system on the distant metastasis-free survival (DMFS) and overall survival (OS) endpoints. However, these results were only reported after a short follow-up. Here, we present the updated data, with a longer follow-up. Material and Methods. CTC count was performed before and after neoadjuvant chemotherapy in 118 patients and correlated to survival. Results. CTC count results were available before and/or after neoadjuvant chemotherapy in 115 patients. After a median follow-up of 70 months, detection of ≥1 CTC/7.5 mL before chemotherapy (N=95) was significantly associated with DMFS (P=0.04) and OS (P=0.03), whereas postchemotherapy CTC detection (N=85) had no significant impact. In multivariable analysis, prechemotherapy CTC and triple negative phenotype were the two independent prognostic factors for survival. We observed that the CTC impact is most significant during the first three years of follow-up. Discussion. We confirm that the detection of CTC is independently associated with a significantly worse outcome, but mainly during the first 3-4 years of follow-up. No prognostic impact is seen in patients who are still relapse-free at this moment. |
| format | Article |
| id | doaj-art-55756a2f27b8419d89d5e441f58bfe9b |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-55756a2f27b8419d89d5e441f58bfe9b2025-02-03T01:26:48ZengWileyInternational Journal of Breast Cancer2090-31702090-31892013-01-01201310.1155/2013/130470130470Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 StudyFrançois-Clément Bidard0Lisa Belin1Suzette Delaloge2Florence Lerebours3Charlotte Ngo4Fabien Reyal5Séverine Alran6Sylvie Giacchetti7Michel Marty8Ronald Lebofsky9Jean-Yves Pierga10Department of Medical Oncology, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Biostatistics, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Medicine, Institut Gustave Roussy, 39 rue Desmoulins, 94805 Villejuif, FranceDepartment of Medical Oncology, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Surgery, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Surgery, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Surgery, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Medical Oncology, Hôpital Saint Louis, 1 Avenue Vellefaux, 75011 Paris, FranceDepartment of Medical Oncology, Hôpital Saint Louis, 1 Avenue Vellefaux, 75011 Paris, FranceLaboratory of Circulating Cancer Biomarker, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceDepartment of Medical Oncology, Institut Curie, 26 rue d'Ulm, 75005 Paris, FranceIntroduction. In non-metastatic breast cancer patients, the REMAGUS02 neoadjuvant study was the first to report a significant impact of circulating tumor cells (CTCs) detection by the CellSearch system on the distant metastasis-free survival (DMFS) and overall survival (OS) endpoints. However, these results were only reported after a short follow-up. Here, we present the updated data, with a longer follow-up. Material and Methods. CTC count was performed before and after neoadjuvant chemotherapy in 118 patients and correlated to survival. Results. CTC count results were available before and/or after neoadjuvant chemotherapy in 115 patients. After a median follow-up of 70 months, detection of ≥1 CTC/7.5 mL before chemotherapy (N=95) was significantly associated with DMFS (P=0.04) and OS (P=0.03), whereas postchemotherapy CTC detection (N=85) had no significant impact. In multivariable analysis, prechemotherapy CTC and triple negative phenotype were the two independent prognostic factors for survival. We observed that the CTC impact is most significant during the first three years of follow-up. Discussion. We confirm that the detection of CTC is independently associated with a significantly worse outcome, but mainly during the first 3-4 years of follow-up. No prognostic impact is seen in patients who are still relapse-free at this moment.http://dx.doi.org/10.1155/2013/130470 |
| spellingShingle | François-Clément Bidard Lisa Belin Suzette Delaloge Florence Lerebours Charlotte Ngo Fabien Reyal Séverine Alran Sylvie Giacchetti Michel Marty Ronald Lebofsky Jean-Yves Pierga Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study International Journal of Breast Cancer |
| title | Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study |
| title_full | Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study |
| title_fullStr | Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study |
| title_full_unstemmed | Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study |
| title_short | Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study |
| title_sort | time dependent prognostic impact of circulating tumor cells detection in non metastatic breast cancer 70 month analysis of the remagus02 study |
| url | http://dx.doi.org/10.1155/2013/130470 |
| work_keys_str_mv | AT francoisclementbidard timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT lisabelin timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT suzettedelaloge timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT florencelerebours timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT charlottengo timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT fabienreyal timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT severinealran timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT sylviegiacchetti timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT michelmarty timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT ronaldlebofsky timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study AT jeanyvespierga timedependentprognosticimpactofcirculatingtumorcellsdetectioninnonmetastaticbreastcancer70monthanalysisoftheremagus02study |