Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer
Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. The aim of this study was to evaluate the changes and the predictive value of serum VAP-1 in patients with thyroid cancer. A...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/6312529 |
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| author | Zhigang Hu Pengxin Zhao Kaili Zhang Leilei Zang Haiying Liao Weiyuan Ma |
| author_facet | Zhigang Hu Pengxin Zhao Kaili Zhang Leilei Zang Haiying Liao Weiyuan Ma |
| author_sort | Zhigang Hu |
| collection | DOAJ |
| description | Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. The aim of this study was to evaluate the changes and the predictive value of serum VAP-1 in patients with thyroid cancer. A total of 126 patients with thyroid nodules and 53 healthy controls participated in this study. The patients were further divided into subgroup 1 (69 cases with benign thyroid nodules) and subgroup 2 (57 cases with thyroid cancer). Serum VAP-1 was measured by time-resolved immunofluorometric assay. Diagnostic value of presurgical VAP-1 for thyroid cancer was conducted by receiver operating characteristic (ROC) curves. Serum levels of VAP-1 were significantly lower in thyroid cancer group than in healthy control and benign thyroid nodule groups. VAP-1 concentrations negatively correlated with serum thyroglobulin (Tg) levels in thyroid cancer patients (r=-0.81; p<0.001). The optimum cut-off value of VAP-1 was 456.6 ng/mL with a 77.4% specificity and 66.7% sensitivity for thyroid cancer diagnosis. Serum VAP-1 decreased in thyroid cancer patients and VAP-1 could be a potential useful adjunct biomarker in the diagnosis of thyroid cancer. |
| format | Article |
| id | doaj-art-5544ee53e81b40d49c494e166142fa51 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5544ee53e81b40d49c494e166142fa512025-02-03T05:59:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/63125296312529Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid CancerZhigang Hu0Pengxin Zhao1Kaili Zhang2Leilei Zang3Haiying Liao4Weiyuan Ma5The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaThe Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaThe Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaThe Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaThe Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaThe Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, ChinaVascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. The aim of this study was to evaluate the changes and the predictive value of serum VAP-1 in patients with thyroid cancer. A total of 126 patients with thyroid nodules and 53 healthy controls participated in this study. The patients were further divided into subgroup 1 (69 cases with benign thyroid nodules) and subgroup 2 (57 cases with thyroid cancer). Serum VAP-1 was measured by time-resolved immunofluorometric assay. Diagnostic value of presurgical VAP-1 for thyroid cancer was conducted by receiver operating characteristic (ROC) curves. Serum levels of VAP-1 were significantly lower in thyroid cancer group than in healthy control and benign thyroid nodule groups. VAP-1 concentrations negatively correlated with serum thyroglobulin (Tg) levels in thyroid cancer patients (r=-0.81; p<0.001). The optimum cut-off value of VAP-1 was 456.6 ng/mL with a 77.4% specificity and 66.7% sensitivity for thyroid cancer diagnosis. Serum VAP-1 decreased in thyroid cancer patients and VAP-1 could be a potential useful adjunct biomarker in the diagnosis of thyroid cancer.http://dx.doi.org/10.1155/2016/6312529 |
| spellingShingle | Zhigang Hu Pengxin Zhao Kaili Zhang Leilei Zang Haiying Liao Weiyuan Ma Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer International Journal of Endocrinology |
| title | Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer |
| title_full | Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer |
| title_fullStr | Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer |
| title_full_unstemmed | Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer |
| title_short | Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer |
| title_sort | evaluation of serum vascular adhesion protein 1 as a potential biomarker in thyroid cancer |
| url | http://dx.doi.org/10.1155/2016/6312529 |
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