Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts
The aim of this study is to determine whether the use of plant extracts like Ecballium elaterium and Senna italica leaf aqueous extracts helps support the activity of meropenem and vancomycin antibiotics against Staphylococcus aureus and Staphylococcus epidermis bacteria. The minimum inhibitory conc...
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| Format: | Article |
| Language: | English |
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Plovdiv University Press
2025-01-01
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| Series: | Journal of BioScience and Biotechnology |
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| Online Access: | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/542/388 |
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| author | Lubna Abdallah Hiba Odeh Huda Salem Thanaa Barham Samah Nazzal Rahaf Kokaly Hana Sa’d Aldeen Amal Holuo |
| author_facet | Lubna Abdallah Hiba Odeh Huda Salem Thanaa Barham Samah Nazzal Rahaf Kokaly Hana Sa’d Aldeen Amal Holuo |
| author_sort | Lubna Abdallah |
| collection | DOAJ |
| description | The aim of this study is to determine whether the use of plant extracts like Ecballium elaterium and Senna italica leaf aqueous extracts helps support the activity of meropenem and vancomycin antibiotics against Staphylococcus aureus and Staphylococcus epidermis bacteria. The minimum inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were used to find out the antibacterial effect of E. elaterium and S. italica extracts in combination with meropenem and vancomycin antibiotics by employing microbroth dilution assay and checkerboard assay. According to the obtained results, all combinations showed a synergistic effect against S. aureus except vancomycin and S. italica combinations which exhibited an additive effect. Moreover, all combinations exhibited an additive effect against S. epidermis except vancomycin and E. elatenium, which showed a synergistic effect. In conclusion, E. elaterium and S. italica leaf aqueous extracts have great potential as sources of antibacterial compounds against microorganisms and they can be used to treat infectious diseases caused by antibiotic-resistant microorganisms. |
| format | Article |
| id | doaj-art-55446124c7ea48488f8cfde244185b8e |
| institution | Kabale University |
| issn | 1314-6238 1314-6246 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Plovdiv University Press |
| record_format | Article |
| series | Journal of BioScience and Biotechnology |
| spelling | doaj-art-55446124c7ea48488f8cfde244185b8e2025-01-28T07:46:35ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462025-01-0113217317710.69085/jbb20242173Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extractsLubna Abdallah0Hiba Odeh1Huda Salem2Thanaa Barham3Samah Nazzal4Rahaf Kokaly5Hana Sa’d Aldeen6Amal Holuo7Biology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineBiology and Biotechnology Department, Faculty of Science, An-Najah National University, Nablus, PalestineThe aim of this study is to determine whether the use of plant extracts like Ecballium elaterium and Senna italica leaf aqueous extracts helps support the activity of meropenem and vancomycin antibiotics against Staphylococcus aureus and Staphylococcus epidermis bacteria. The minimum inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were used to find out the antibacterial effect of E. elaterium and S. italica extracts in combination with meropenem and vancomycin antibiotics by employing microbroth dilution assay and checkerboard assay. According to the obtained results, all combinations showed a synergistic effect against S. aureus except vancomycin and S. italica combinations which exhibited an additive effect. Moreover, all combinations exhibited an additive effect against S. epidermis except vancomycin and E. elatenium, which showed a synergistic effect. In conclusion, E. elaterium and S. italica leaf aqueous extracts have great potential as sources of antibacterial compounds against microorganisms and they can be used to treat infectious diseases caused by antibiotic-resistant microorganisms.https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/542/388ecballium elateriumsenna italicasynergymeropenemvancomycinantibiotics |
| spellingShingle | Lubna Abdallah Hiba Odeh Huda Salem Thanaa Barham Samah Nazzal Rahaf Kokaly Hana Sa’d Aldeen Amal Holuo Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts Journal of BioScience and Biotechnology ecballium elaterium senna italica synergy meropenem vancomycin antibiotics |
| title | Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts |
| title_full | Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts |
| title_fullStr | Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts |
| title_full_unstemmed | Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts |
| title_short | Synergistic effect of meropenem and vancomycin antibiotics with Ecballium elaterium and Senna italica extracts |
| title_sort | synergistic effect of meropenem and vancomycin antibiotics with ecballium elaterium and senna italica extracts |
| topic | ecballium elaterium senna italica synergy meropenem vancomycin antibiotics |
| url | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/542/388 |
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