Synthesis of 1H-pyrazolo[3,4-b]pyridine analogues
Many compounds containing the pyrazolo[3,4-b]pyridine scaffold have been found to have various pharmacological activities such as anticancer, anti-inflammatory, anti-bacterial, antihyperglycemic, and anxiolytic properties. In general, low water solubility often hinders bioassay screening of small mo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221171562500058X |
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| Summary: | Many compounds containing the pyrazolo[3,4-b]pyridine scaffold have been found to have various pharmacological activities such as anticancer, anti-inflammatory, anti-bacterial, antihyperglycemic, and anxiolytic properties. In general, low water solubility often hinders bioassay screening of small molecules. In this work, we have prepared a series of 1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid analogues through the condensation of 5-aminopyrazoles with aromatic aldehydes and pyruvic acid. We then converted the carboxylic acid handle on these heterocycles into the corresponding sodium salt, which improved the water solubility. |
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| ISSN: | 2211-7156 |