Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020
BackgroundOxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, limited studies have explored the relationship between OBS and...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1493253/full |
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| author | Mingjun Ma Huanying Xu Huanying Xu Kexin Wang Yanfen Chen Ting Pan Qiaoling Zhu Qiaoling Zhu |
| author_facet | Mingjun Ma Huanying Xu Huanying Xu Kexin Wang Yanfen Chen Ting Pan Qiaoling Zhu Qiaoling Zhu |
| author_sort | Mingjun Ma |
| collection | DOAJ |
| description | BackgroundOxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, limited studies have explored the relationship between OBS and infertility.MethodsWe performed a cross-sectional study including 2,664 women aged 20–45 years, based on data from the 2013–2020 National Health and Nutrition Examination Survey (NHANES). The OBS was derived from 16 dietary components and 4 lifestyle factors. We used multivariate logistic regression analysis to examine the association between OBS and infertility.ResultsThe analysis revealed a significant negative association between higher OBS and infertility risk, with an odds ratio (OR) of 0.98 (95% CI, 0.95–1.00) after full adjustment. Compared to the first quartile of OBS, the second, third, and fourth quartiles showed ORs of 0.71 (95% CI, 0.45–1.11), 0.79 (95% CI, 0.51–1.22), and 0.57 (95% CI, 0.35–0.92), respectively. Similarly, women in the highest dietary OBS and lifestyle OBS quartiles had a lower infertility risk compared to those in the lowest quartiles, with ORs of 0.60 (95% CI, 0.39–0.94) and 0.54 (95% CI, 0.32–0.93), respectively. Furthermore, subgroup analysis indicated that the association between the fourth quartile of OBS and infertility remained consistent, except among women with other ethnicities—including multi-racial, and college graduate or higher.ConclusionThese findings suggest that high dietary OBS and lifestyle OBS are associated with a lower risk of infertility. |
| format | Article |
| id | doaj-art-55325e5ec3bc4212a3f5aa54e898768a |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-55325e5ec3bc4212a3f5aa54e898768a2025-02-04T05:28:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.14932531493253Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020Mingjun Ma0Huanying Xu1Huanying Xu2Kexin Wang3Yanfen Chen4Ting Pan5Qiaoling Zhu6Qiaoling Zhu7Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, ChinaFoshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, ChinaDepartment of TCM Gynecology, Foshan Fosun Chancheng Hospital, Foshan, Guangdong, ChinaFoshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, ChinaFoshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, ChinaDepartment of TCM Gynecology, Foshan Fosun Chancheng Hospital, Foshan, Guangdong, ChinaFoshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, ChinaDepartment of TCM Gynecology, Foshan Fosun Chancheng Hospital, Foshan, Guangdong, ChinaBackgroundOxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, limited studies have explored the relationship between OBS and infertility.MethodsWe performed a cross-sectional study including 2,664 women aged 20–45 years, based on data from the 2013–2020 National Health and Nutrition Examination Survey (NHANES). The OBS was derived from 16 dietary components and 4 lifestyle factors. We used multivariate logistic regression analysis to examine the association between OBS and infertility.ResultsThe analysis revealed a significant negative association between higher OBS and infertility risk, with an odds ratio (OR) of 0.98 (95% CI, 0.95–1.00) after full adjustment. Compared to the first quartile of OBS, the second, third, and fourth quartiles showed ORs of 0.71 (95% CI, 0.45–1.11), 0.79 (95% CI, 0.51–1.22), and 0.57 (95% CI, 0.35–0.92), respectively. Similarly, women in the highest dietary OBS and lifestyle OBS quartiles had a lower infertility risk compared to those in the lowest quartiles, with ORs of 0.60 (95% CI, 0.39–0.94) and 0.54 (95% CI, 0.32–0.93), respectively. Furthermore, subgroup analysis indicated that the association between the fourth quartile of OBS and infertility remained consistent, except among women with other ethnicities—including multi-racial, and college graduate or higher.ConclusionThese findings suggest that high dietary OBS and lifestyle OBS are associated with a lower risk of infertility.https://www.frontiersin.org/articles/10.3389/fnut.2025.1493253/fulloxidative balance scorefemale infertilitydietary antioxidantsoxidative stressNHANES |
| spellingShingle | Mingjun Ma Huanying Xu Huanying Xu Kexin Wang Yanfen Chen Ting Pan Qiaoling Zhu Qiaoling Zhu Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 Frontiers in Nutrition oxidative balance score female infertility dietary antioxidants oxidative stress NHANES |
| title | Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 |
| title_full | Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 |
| title_fullStr | Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 |
| title_full_unstemmed | Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 |
| title_short | Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 |
| title_sort | higher oxidative balance score is associated with a decreased risk of infertility an analysis of nhanes 2013 2020 |
| topic | oxidative balance score female infertility dietary antioxidants oxidative stress NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1493253/full |
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