Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG
ObjectiveThis study investigates the interplay between muscle strength, information processing speed, EEG-specific biomarkers, and cognitive function in elderly individuals with cognitive impairments, emphasizing the mediating roles of information processing speed and EEG-specific biomarkers.MethodA...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1496725/full |
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| author | Xin Xin Qing Liu Shuqi Jia Shufan Li Peng Wang Xingze Wang Xing Wang |
| author_facet | Xin Xin Qing Liu Shuqi Jia Shufan Li Peng Wang Xingze Wang Xing Wang |
| author_sort | Xin Xin |
| collection | DOAJ |
| description | ObjectiveThis study investigates the interplay between muscle strength, information processing speed, EEG-specific biomarkers, and cognitive function in elderly individuals with cognitive impairments, emphasizing the mediating roles of information processing speed and EEG-specific biomarkers.MethodA cross-sectional study design was employed to recruit 151 elderly participants. The participants underwent grip strength and 30-s sit-to-stand tests to assess muscle strength, completed the Trail Making Test part A (TMT-A) and the Symbol Digit Modality Test (SDMT) to evaluate information processing speed, and utilized the Montreal Cognitive Assessment (MOCA) to gauge cognitive function. Additionally, EEG signals were recorded for 5 min to capture neural activity.ResultsThe difference in information processing speed among elderly individuals with varying degrees of cognitive impairment was statistically significant (p < 0.001). A significant negative correlation was observed between the MoCA score and the time consumption of TMT-A (r = −0.402, p < 0.01), and a significant positive correlation was found between the MoCA score and the SDMT score (r = 0.609, p < 0.01). Grip strength was negatively correlated with the time consumption of TMT-A (r = −0.336, p < 0.01) and positively correlated with the SDMT score (r = 0.336, p < 0.01). A significant negative correlation was found between the 30-s sit-to-stand test and the time consumption of TMT-A (r = −0.273, p < 0.01), and a significant positive correlation was observed between the 30-s sit-to-stand test and the SDMT score (r = 0.372, p < 0.01). Additionally, we observed that the α1 power value indicators were significantly correlated with the MoCA score, the time consumption of TMT-A, and the SDMT score (all p < 0.01). The α1 power values at F7 + F8 and T5 + T6 were identified as sensitive EEG indicators for muscle strength and information processing speed. The EEG-specific indicators (B = 0.019, 95% CI: 0.003, 0.047) and information processing speed (B = 0.137, 95% CI: 0.096, 0.292) were found to partially mediate the relationship between grip strength and MoCA scores, with information processing speed exerting a stronger mediating effect.ConclusionSpecific patterns were observed in the EEG of elderly individuals with cognitive impairments, which could objectively assess the risk of cognitive decline in this population. Muscle strength, information processing speed, and EEG-specific biomarkers were closely associated with cognitive function in elderly individuals. The potential pathway of interaction—muscle strength → EEG-specific biomarkers → information processing speed → cognitive function—provides valuable insights into advancing the field of cognitive research in the elderly. |
| format | Article |
| id | doaj-art-552f1e607faf41c8a578925015b78619 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-552f1e607faf41c8a578925015b786192025-01-20T07:20:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011710.3389/fnagi.2025.14967251496725Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEGXin Xin0Qing Liu1Shuqi Jia2Shufan Li3Peng Wang4Xingze Wang5Xing Wang6School of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Huzhou University, Huzhou, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaObjectiveThis study investigates the interplay between muscle strength, information processing speed, EEG-specific biomarkers, and cognitive function in elderly individuals with cognitive impairments, emphasizing the mediating roles of information processing speed and EEG-specific biomarkers.MethodA cross-sectional study design was employed to recruit 151 elderly participants. The participants underwent grip strength and 30-s sit-to-stand tests to assess muscle strength, completed the Trail Making Test part A (TMT-A) and the Symbol Digit Modality Test (SDMT) to evaluate information processing speed, and utilized the Montreal Cognitive Assessment (MOCA) to gauge cognitive function. Additionally, EEG signals were recorded for 5 min to capture neural activity.ResultsThe difference in information processing speed among elderly individuals with varying degrees of cognitive impairment was statistically significant (p < 0.001). A significant negative correlation was observed between the MoCA score and the time consumption of TMT-A (r = −0.402, p < 0.01), and a significant positive correlation was found between the MoCA score and the SDMT score (r = 0.609, p < 0.01). Grip strength was negatively correlated with the time consumption of TMT-A (r = −0.336, p < 0.01) and positively correlated with the SDMT score (r = 0.336, p < 0.01). A significant negative correlation was found between the 30-s sit-to-stand test and the time consumption of TMT-A (r = −0.273, p < 0.01), and a significant positive correlation was observed between the 30-s sit-to-stand test and the SDMT score (r = 0.372, p < 0.01). Additionally, we observed that the α1 power value indicators were significantly correlated with the MoCA score, the time consumption of TMT-A, and the SDMT score (all p < 0.01). The α1 power values at F7 + F8 and T5 + T6 were identified as sensitive EEG indicators for muscle strength and information processing speed. The EEG-specific indicators (B = 0.019, 95% CI: 0.003, 0.047) and information processing speed (B = 0.137, 95% CI: 0.096, 0.292) were found to partially mediate the relationship between grip strength and MoCA scores, with information processing speed exerting a stronger mediating effect.ConclusionSpecific patterns were observed in the EEG of elderly individuals with cognitive impairments, which could objectively assess the risk of cognitive decline in this population. Muscle strength, information processing speed, and EEG-specific biomarkers were closely associated with cognitive function in elderly individuals. The potential pathway of interaction—muscle strength → EEG-specific biomarkers → information processing speed → cognitive function—provides valuable insights into advancing the field of cognitive research in the elderly.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1496725/fullmuscle strengthinformation processing speedcognitive impairmentthe elderlyEEG |
| spellingShingle | Xin Xin Qing Liu Shuqi Jia Shufan Li Peng Wang Xingze Wang Xing Wang Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG Frontiers in Aging Neuroscience muscle strength information processing speed cognitive impairment the elderly EEG |
| title | Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG |
| title_full | Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG |
| title_fullStr | Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG |
| title_full_unstemmed | Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG |
| title_short | Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG |
| title_sort | correlation of muscle strength information processing speed and cognitive function in the elderly with cognitive impairment evidence from eeg |
| topic | muscle strength information processing speed cognitive impairment the elderly EEG |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1496725/full |
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