Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols
ABSTRACT Background Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury. Objectives To evaluate perioperative changes in high‐sensitivity cardiac troponin I (hs‐cTnI) concentration during ovariohysterectomy in cats undergoing three different...
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Wiley
2024-11-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.70050 |
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| author | Tarik Safak Oznur Yılmaz‐Koç Ebru Karakaya‐Bilen |
| author_facet | Tarik Safak Oznur Yılmaz‐Koç Ebru Karakaya‐Bilen |
| author_sort | Tarik Safak |
| collection | DOAJ |
| description | ABSTRACT Background Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury. Objectives To evaluate perioperative changes in high‐sensitivity cardiac troponin I (hs‐cTnI) concentration during ovariohysterectomy in cats undergoing three different anaesthesia protocols. Methods Twenty‐one female mixed‐breed cats owned by clients aged (2.2 ± 0.7 years) and weight (3.2 ± 0.5 kg) were included in our study. The cats were divided into three groups: propofol–isoflurane (PI) group (n = 7), xylazine–ketamine (XK) group (n = 7) and xylazine–isoflurane (XI) group (n = 7). After pre‐anaesthetic propofol (6 mg/kg IV) was administered to cats in Group PI, a mask was placed, and anaesthesia was maintained with 3.0% isoflurane in oxygen. Cats in Group XK underwent general anesthetization with xylazine hydrochloride (2 mg/kg IM) and, 10 min later, ketamine hydrochloride (10 mg/kg IM). Cats in Group XI were administered xylazine hydrochloride (2 mg/kg IM), and then anaesthesia (3.0% isoflurane and oxygen) was continued with a mask. Blood samples were collected from all cats; preoperatively and postoperatively at 0 and 12 h (Pre‐, Post‐0 h and Post‐12 h, respectively). Serum hs‐cTnI concentrations were measured with the Advia Centaur TnI‐Ultra. Results In all 21 cats, hs‐cTnI concentration increased at Post‐0 h and 12 h measurement points compared to Pre‐. In the XK group, hs‐cTnI concentrations exhibited a significant increase at the Post‐0 h (51.30 ng/L) and Post‐12 h (157.70 ng/L) time points compared to Pre‐ (6.70 ng/L) (p < 0.05). Conclusions The XK group increased the concentration of hs‐cTnI more than other protocols. In the PI group, the increase in hs‐cTnI concentrations at Post‐0 and 12 h increased less than the other two groups (p < 0.05). The PI group was found to induce less myocardial damage. |
| format | Article |
| id | doaj-art-550733c24fa445d9a2b6561ea41e009b |
| institution | Kabale University |
| issn | 2053-1095 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Veterinary Medicine and Science |
| spelling | doaj-art-550733c24fa445d9a2b6561ea41e009b2025-01-20T17:16:44ZengWileyVeterinary Medicine and Science2053-10952024-11-01106n/an/a10.1002/vms3.70050Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia ProtocolsTarik Safak0Oznur Yılmaz‐Koç1Ebru Karakaya‐Bilen2Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Kastamonu University Kastamonu TürkiyeDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine Siirt University Siirt TürkiyeDepartment of Obstetrics and Gynecology, Faculty of Ceyhan Veterinary Medicine Cukurova University Adana TürkiyeABSTRACT Background Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury. Objectives To evaluate perioperative changes in high‐sensitivity cardiac troponin I (hs‐cTnI) concentration during ovariohysterectomy in cats undergoing three different anaesthesia protocols. Methods Twenty‐one female mixed‐breed cats owned by clients aged (2.2 ± 0.7 years) and weight (3.2 ± 0.5 kg) were included in our study. The cats were divided into three groups: propofol–isoflurane (PI) group (n = 7), xylazine–ketamine (XK) group (n = 7) and xylazine–isoflurane (XI) group (n = 7). After pre‐anaesthetic propofol (6 mg/kg IV) was administered to cats in Group PI, a mask was placed, and anaesthesia was maintained with 3.0% isoflurane in oxygen. Cats in Group XK underwent general anesthetization with xylazine hydrochloride (2 mg/kg IM) and, 10 min later, ketamine hydrochloride (10 mg/kg IM). Cats in Group XI were administered xylazine hydrochloride (2 mg/kg IM), and then anaesthesia (3.0% isoflurane and oxygen) was continued with a mask. Blood samples were collected from all cats; preoperatively and postoperatively at 0 and 12 h (Pre‐, Post‐0 h and Post‐12 h, respectively). Serum hs‐cTnI concentrations were measured with the Advia Centaur TnI‐Ultra. Results In all 21 cats, hs‐cTnI concentration increased at Post‐0 h and 12 h measurement points compared to Pre‐. In the XK group, hs‐cTnI concentrations exhibited a significant increase at the Post‐0 h (51.30 ng/L) and Post‐12 h (157.70 ng/L) time points compared to Pre‐ (6.70 ng/L) (p < 0.05). Conclusions The XK group increased the concentration of hs‐cTnI more than other protocols. In the PI group, the increase in hs‐cTnI concentrations at Post‐0 and 12 h increased less than the other two groups (p < 0.05). The PI group was found to induce less myocardial damage.https://doi.org/10.1002/vms3.70050cardiac troponin Icatisofluraneketamine hydrochloridepropofolxylazine hydrochloride |
| spellingShingle | Tarik Safak Oznur Yılmaz‐Koç Ebru Karakaya‐Bilen Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols Veterinary Medicine and Science cardiac troponin I cat isoflurane ketamine hydrochloride propofol xylazine hydrochloride |
| title | Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols |
| title_full | Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols |
| title_fullStr | Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols |
| title_full_unstemmed | Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols |
| title_short | Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols |
| title_sort | perioperative change of high sensitive cardiac troponin i concentration in cats according to three different anaesthesia protocols |
| topic | cardiac troponin I cat isoflurane ketamine hydrochloride propofol xylazine hydrochloride |
| url | https://doi.org/10.1002/vms3.70050 |
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