Oxidative Distress in Patients with Polytrauma
Polytrauma is a serious threat to human life not only due to its direct damage to vital organs, but also to the development of significant oxidative distress that gives rise to multiple organ dysfunction. At the same time, the risk of lifethreatening infectious complications increases.Objective: to...
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| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2014-06-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1337 |
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| author | M. Sh. Khubutia A. K. Shabanov G. V. Bulava A. G. Dorfman Z. M. Zainudinov M. V. Skulachev A. N. Kuzovlev O. A. Grebenchikov A. A. Sergeev M. I. Shpitonkov G. Yu. Maltsev |
| author_facet | M. Sh. Khubutia A. K. Shabanov G. V. Bulava A. G. Dorfman Z. M. Zainudinov M. V. Skulachev A. N. Kuzovlev O. A. Grebenchikov A. A. Sergeev M. I. Shpitonkov G. Yu. Maltsev |
| author_sort | M. Sh. Khubutia |
| collection | DOAJ |
| description | Polytrauma is a serious threat to human life not only due to its direct damage to vital organs, but also to the development of significant oxidative distress that gives rise to multiple organ dysfunction. At the same time, the risk of lifethreatening infectious complications increases.Objective: to study oxidative distress over time and its association with early pulmonary infectious complications in patients with polytrauma.Subjects and methods. The authors examined 35 patients with polytrauma in the first 6—12 and 12—24 hours and 3, 5—7, and 10 days after injury and 25 healthy volunteers. Having regard to the development of pulmonary infectious complications, they formed two comparison groups of patients: 1) 15 patients without pneumonia and 2) 20 patients with pneumonia. The investigation used the antioxidant index (AOI) considering the activity of erythrocyte enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the degree of lipid peroxidation in the plasma (dienic conjugates and malonic dialdehyde) to estimate the balance between oxidative lesions and the performance of the body's antioxidant systems.Results. In both groups, the AOI reflects the oxidative stress state, as substantiated by negative values for the AOI with its normal value equal to zero. However, with the virtually parallel nature of AOI changes after injury in the patients with pneumonia, the values of the index were significantly lower than in those without complications within the first 6—12 and 12—24 hours and 5—7 days (p<0.05).Conclusion. This investigation has indicated that the AOI is an early candidate biomarker for the risk of infectious complications and its values are of prognostic value just within the first hours after injury. |
| format | Article |
| id | doaj-art-54f6b586ecd64ee28b38a4f97ee573b2 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-54f6b586ecd64ee28b38a4f97ee573b22025-08-20T03:18:49ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102014-06-01102233010.15360/1813-9779-2014-2-23-301337Oxidative Distress in Patients with PolytraumaM. Sh. Khubutia0A. K. Shabanov1G. V. Bulava2A. G. Dorfman3Z. M. Zainudinov4M. V. Skulachev5A. N. Kuzovlev6O. A. Grebenchikov7A. A. Sergeev8M. I. Shpitonkov9G. Yu. Maltsev10N. V. Sklifosovsky Research Institute of Emergency Medicine, MoscowN. V. Sklifosovsky Research Institute of Emergency Medicine, MoscowN. V. Sklifosovsky Research Institute of Emergency Medicine, MoscowN. V. Sklifosovsky Research Institute of Emergency Medicine, MoscowResearch Institute of Nutrition, Russian Academy of Medical Sciences, MoscowInstitute of Mitoengineering, M. V. Lomonosov Moscow State UniversityV. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowV. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowN. V. Sklifosovsky Research Institute of Emergency Medicine, MoscowA. A. Dorodnitsyn Computer Center, Russian Academy of Sciences, MoscowResearch Institute of Nutrition, Russian Academy of Medical Sciences, MoscowPolytrauma is a serious threat to human life not only due to its direct damage to vital organs, but also to the development of significant oxidative distress that gives rise to multiple organ dysfunction. At the same time, the risk of lifethreatening infectious complications increases.Objective: to study oxidative distress over time and its association with early pulmonary infectious complications in patients with polytrauma.Subjects and methods. The authors examined 35 patients with polytrauma in the first 6—12 and 12—24 hours and 3, 5—7, and 10 days after injury and 25 healthy volunteers. Having regard to the development of pulmonary infectious complications, they formed two comparison groups of patients: 1) 15 patients without pneumonia and 2) 20 patients with pneumonia. The investigation used the antioxidant index (AOI) considering the activity of erythrocyte enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the degree of lipid peroxidation in the plasma (dienic conjugates and malonic dialdehyde) to estimate the balance between oxidative lesions and the performance of the body's antioxidant systems.Results. In both groups, the AOI reflects the oxidative stress state, as substantiated by negative values for the AOI with its normal value equal to zero. However, with the virtually parallel nature of AOI changes after injury in the patients with pneumonia, the values of the index were significantly lower than in those without complications within the first 6—12 and 12—24 hours and 5—7 days (p<0.05).Conclusion. This investigation has indicated that the AOI is an early candidate biomarker for the risk of infectious complications and its values are of prognostic value just within the first hours after injury.https://www.reanimatology.com/rmt/article/view/1337polytrauma, antioxidant status, oxidative distress, iss, infectious complications, pneumonia, mortality, mechanical ventilation |
| spellingShingle | M. Sh. Khubutia A. K. Shabanov G. V. Bulava A. G. Dorfman Z. M. Zainudinov M. V. Skulachev A. N. Kuzovlev O. A. Grebenchikov A. A. Sergeev M. I. Shpitonkov G. Yu. Maltsev Oxidative Distress in Patients with Polytrauma Общая реаниматология polytrauma, antioxidant status, oxidative distress, iss, infectious complications, pneumonia, mortality, mechanical ventilation |
| title | Oxidative Distress in Patients with Polytrauma |
| title_full | Oxidative Distress in Patients with Polytrauma |
| title_fullStr | Oxidative Distress in Patients with Polytrauma |
| title_full_unstemmed | Oxidative Distress in Patients with Polytrauma |
| title_short | Oxidative Distress in Patients with Polytrauma |
| title_sort | oxidative distress in patients with polytrauma |
| topic | polytrauma, antioxidant status, oxidative distress, iss, infectious complications, pneumonia, mortality, mechanical ventilation |
| url | https://www.reanimatology.com/rmt/article/view/1337 |
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