Dual T/NK cell engagement via B7-H6-targeted bispecific antibodies and IL-15 eradicates chemo-resistant solid tumors

Dual T/NK cell engagement via B7-H6-targeted bispecific antibodies and IL-15 eradicates chemo-resistant solid tumors

IntroductionB7-H6, a tumor-specific immune checkpoint molecule within the B7 family, represents a promising therapeutic target due to its selective overexpression in malignancies and negligible expression in normal tissues.MethodHere, we developed bispecific antibodies (BsAbs) targeting B7-H6 to red...

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Bibliographic Details
Main Authors: Xuqian Ma, Huixia He, Yuankui Zhu, Dianbao Zuo, FangLin Wang, Mingqian Feng, Kangkang Ji, Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
B7-H6
bispecific antibodies
NK cells
IL-15Rα sushi
solid tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1625813/full
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