Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents
Dyslipidemia, characterized by abnormal blood lipid levels, is a significant risk factor for cardiovascular diseases (CVDs). Natural plant extracts, particularly olive extract, have garnered attention for their potential therapeutic effects. This study investigates the hypolipidemic effects of olive...
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Taylor & Francis Group
2025-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2463491 |
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| author | Wafa Laaboudi Naglaa S. Ashmawy Naoufal El Hachlafi Fahad M Alshabrmi Sulaiman Mohammed Alnasseri Hamza Assaggaf Ahmed Qasem Ammar AL-Fargah Saleh M. Al-Maaqar Hanae Naceiri Mrabti |
| author_facet | Wafa Laaboudi Naglaa S. Ashmawy Naoufal El Hachlafi Fahad M Alshabrmi Sulaiman Mohammed Alnasseri Hamza Assaggaf Ahmed Qasem Ammar AL-Fargah Saleh M. Al-Maaqar Hanae Naceiri Mrabti |
| author_sort | Wafa Laaboudi |
| collection | DOAJ |
| description | Dyslipidemia, characterized by abnormal blood lipid levels, is a significant risk factor for cardiovascular diseases (CVDs). Natural plant extracts, particularly olive extract, have garnered attention for their potential therapeutic effects. This study investigates the hypolipidemic effects of olive tree extract (OTE) in hyperlipidemic rats. Male Wistar rats were fed a hypercholesterolemic diet for two weeks, followed by three weeks of daily treatment with OTE. The results indicate that OTE effectively reduced triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels while elevating high-density lipoprotein cholesterol (HDL-C) levels. Furthermore, OTE demonstrated superior efficacy in improving lipid profiles compared to simvastatin, a commonly used lipid-lowering drug. Additionally, OTE administration positively influenced the heart disease risk ratio and normalized renal function parameters. These findings underscore the potential of OTE as a natural intervention for managing dyslipidemia and reducing the risk of CVDs. Overall, OTE exhibits promising hypolipidemic properties, highlighting its therapeutic potential in addressing lipid disorders and associated cardiovascular risks. |
| format | Article |
| id | doaj-art-54ea754dbfef4e33b113c0b3992febfe |
| institution | DOAJ |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-54ea754dbfef4e33b113c0b3992febfe2025-08-20T03:12:51ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452025-12-0123110.1080/19476337.2025.2463491Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituentsWafa Laaboudi0Naglaa S. Ashmawy1Naoufal El Hachlafi2Fahad M Alshabrmi3Sulaiman Mohammed Alnasseri4Hamza Assaggaf5Ahmed Qasem6Ammar AL-Fargah7Saleh M. Al-Maaqar8Hanae Naceiri Mrabti9Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technology, Sidi Mohammed Ben Abdellah University, Fez, MoroccoDepartment of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesLaboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Fez, MoroccoDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi ArabiaDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudia ArabiaDepartment of Biology, Faculty of Education, Albaydha University, Al-Baydha, YemenLaboratory of Applied Organic Chemistry, Faculty of Sciences and Technology, Sidi Mohammed Ben Abdellah University, Fez, MoroccoDyslipidemia, characterized by abnormal blood lipid levels, is a significant risk factor for cardiovascular diseases (CVDs). Natural plant extracts, particularly olive extract, have garnered attention for their potential therapeutic effects. This study investigates the hypolipidemic effects of olive tree extract (OTE) in hyperlipidemic rats. Male Wistar rats were fed a hypercholesterolemic diet for two weeks, followed by three weeks of daily treatment with OTE. The results indicate that OTE effectively reduced triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels while elevating high-density lipoprotein cholesterol (HDL-C) levels. Furthermore, OTE demonstrated superior efficacy in improving lipid profiles compared to simvastatin, a commonly used lipid-lowering drug. Additionally, OTE administration positively influenced the heart disease risk ratio and normalized renal function parameters. These findings underscore the potential of OTE as a natural intervention for managing dyslipidemia and reducing the risk of CVDs. Overall, OTE exhibits promising hypolipidemic properties, highlighting its therapeutic potential in addressing lipid disorders and associated cardiovascular risks.https://www.tandfonline.com/doi/10.1080/19476337.2025.2463491Hypercholesterolemiaolive tree extractpolyphenolsflavonoidsratin vivo |
| spellingShingle | Wafa Laaboudi Naglaa S. Ashmawy Naoufal El Hachlafi Fahad M Alshabrmi Sulaiman Mohammed Alnasseri Hamza Assaggaf Ahmed Qasem Ammar AL-Fargah Saleh M. Al-Maaqar Hanae Naceiri Mrabti Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents CyTA - Journal of Food Hypercholesterolemia olive tree extract polyphenols flavonoids rat in vivo |
| title | Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents |
| title_full | Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents |
| title_fullStr | Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents |
| title_full_unstemmed | Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents |
| title_short | Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents |
| title_sort | impact of olive tree extract on hyperlipidemia in rats hplc analysis of bioactive constituents |
| topic | Hypercholesterolemia olive tree extract polyphenols flavonoids rat in vivo |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2025.2463491 |
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