Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application
Neural crest stem cells (NCSCs) represent a transient and multipotent cell population that contributes to numerous anatomical structures such as peripheral nervous system, teeth, and cornea. NCSC maldevelopment is related to various human diseases including pigmentation abnormalities, disorders affe...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7695836 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549792805289984 |
|---|---|
| author | Qian Zhu Qiqi Lu Rong Gao Tong Cao |
| author_facet | Qian Zhu Qiqi Lu Rong Gao Tong Cao |
| author_sort | Qian Zhu |
| collection | DOAJ |
| description | Neural crest stem cells (NCSCs) represent a transient and multipotent cell population that contributes to numerous anatomical structures such as peripheral nervous system, teeth, and cornea. NCSC maldevelopment is related to various human diseases including pigmentation abnormalities, disorders affecting autonomic nervous system, and malformations of teeth, eyes, and hearts. As human pluripotent stem cells including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can serve as an unlimited cell source to generate NCSCs, hESC/hiPSC-derived NCSCs can be a valuable tool to study the underlying mechanisms of NCSC-associated diseases, which paves the way for future therapies for these abnormalities. In addition, hESC/hiPSC-derived NCSCs with the capability of differentiating to various cell types are highly promising for clinical organ repair and regeneration. In this review, we first discuss NCSC generation methods from human pluripotent stem cells and differentiation mechanism of NCSCs. Then we focus on the clinical application potential of hESC/hiPSC-derived NCSCs on peripheral nerve injuries, corneal blindness, tooth regeneration, pathological melanogenesis, Hirschsprung disease, and cardiac repair and regeneration. |
| format | Article |
| id | doaj-art-54de5f161a8c44b4b61be406f457d787 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-54de5f161a8c44b4b61be406f457d7872025-02-03T06:08:35ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/76958367695836Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical ApplicationQian Zhu0Qiqi Lu1Rong Gao2Tong Cao3Faculty of Dentistry, National University of Singapore, 119083, SingaporeFaculty of Dentistry, National University of Singapore, 119083, SingaporeFaculty of Dentistry, National University of Singapore, 119083, SingaporeFaculty of Dentistry, National University of Singapore, 119083, SingaporeNeural crest stem cells (NCSCs) represent a transient and multipotent cell population that contributes to numerous anatomical structures such as peripheral nervous system, teeth, and cornea. NCSC maldevelopment is related to various human diseases including pigmentation abnormalities, disorders affecting autonomic nervous system, and malformations of teeth, eyes, and hearts. As human pluripotent stem cells including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can serve as an unlimited cell source to generate NCSCs, hESC/hiPSC-derived NCSCs can be a valuable tool to study the underlying mechanisms of NCSC-associated diseases, which paves the way for future therapies for these abnormalities. In addition, hESC/hiPSC-derived NCSCs with the capability of differentiating to various cell types are highly promising for clinical organ repair and regeneration. In this review, we first discuss NCSC generation methods from human pluripotent stem cells and differentiation mechanism of NCSCs. Then we focus on the clinical application potential of hESC/hiPSC-derived NCSCs on peripheral nerve injuries, corneal blindness, tooth regeneration, pathological melanogenesis, Hirschsprung disease, and cardiac repair and regeneration.http://dx.doi.org/10.1155/2016/7695836 |
| spellingShingle | Qian Zhu Qiqi Lu Rong Gao Tong Cao Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application Stem Cells International |
| title | Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application |
| title_full | Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application |
| title_fullStr | Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application |
| title_full_unstemmed | Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application |
| title_short | Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application |
| title_sort | prospect of human pluripotent stem cell derived neural crest stem cells in clinical application |
| url | http://dx.doi.org/10.1155/2016/7695836 |
| work_keys_str_mv | AT qianzhu prospectofhumanpluripotentstemcellderivedneuralcreststemcellsinclinicalapplication AT qiqilu prospectofhumanpluripotentstemcellderivedneuralcreststemcellsinclinicalapplication AT ronggao prospectofhumanpluripotentstemcellderivedneuralcreststemcellsinclinicalapplication AT tongcao prospectofhumanpluripotentstemcellderivedneuralcreststemcellsinclinicalapplication |