Hypoglycemic natural products with in vivo activities and their mechanisms: a review
Diabetes mellitus (DM) is a metabolic disorder disease, and the number of diabetic patients will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are used for treating diabetes. However, these drugs cannot completely meet patients’ needs, due to diabetic complicat...
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000398 |
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| author | Wenyi Ma Longgao Xiao Haiyang Liu Xiaojiang Hao |
| author_facet | Wenyi Ma Longgao Xiao Haiyang Liu Xiaojiang Hao |
| author_sort | Wenyi Ma |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic disorder disease, and the number of diabetic patients will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are used for treating diabetes. However, these drugs cannot completely meet patients’ needs, due to diabetic complications need to be addressed along with diabetes, such as nephropathy, and cardiovascular diseases. Besides, more types of drugs need to be provided for more choices. Hence, scientists still seek lead compounds with hypoglycemic effects. Natural products (NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side effects. And some of them show effects on diabetic complications, which is a significant idea for drug development. This review aims to summarize natural products with hypoglycemic effects and their details, such as potential mechanisms, biological data, and particularly their advantages in treating diabetes. Considering the huge number of NPs was reported with anti-diabetic activity, and some of them need to be re-validated, this review focuses on the bioactive compounds with in vivo activities. In the end, the trend of natural products treating diabetes was discussed. We hope this review provide a comprehensive and convincing summary, thus lending support to anti-diabetic natural products research. |
| format | Article |
| id | doaj-art-54d9542c48ac4cee9dc44e59a17eed5c |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-54d9542c48ac4cee9dc44e59a17eed5c2025-02-03T05:16:11ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111510871100Hypoglycemic natural products with in vivo activities and their mechanisms: a reviewWenyi Ma0Longgao Xiao1Haiyang Liu2Xiaojiang Hao3State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Corresponding authors at: State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Corresponding authors at: State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.Diabetes mellitus (DM) is a metabolic disorder disease, and the number of diabetic patients will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are used for treating diabetes. However, these drugs cannot completely meet patients’ needs, due to diabetic complications need to be addressed along with diabetes, such as nephropathy, and cardiovascular diseases. Besides, more types of drugs need to be provided for more choices. Hence, scientists still seek lead compounds with hypoglycemic effects. Natural products (NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side effects. And some of them show effects on diabetic complications, which is a significant idea for drug development. This review aims to summarize natural products with hypoglycemic effects and their details, such as potential mechanisms, biological data, and particularly their advantages in treating diabetes. Considering the huge number of NPs was reported with anti-diabetic activity, and some of them need to be re-validated, this review focuses on the bioactive compounds with in vivo activities. In the end, the trend of natural products treating diabetes was discussed. We hope this review provide a comprehensive and convincing summary, thus lending support to anti-diabetic natural products research.http://www.sciencedirect.com/science/article/pii/S2213453022000398DiabetesNatural productsHypoglycemic effectsMechanism |
| spellingShingle | Wenyi Ma Longgao Xiao Haiyang Liu Xiaojiang Hao Hypoglycemic natural products with in vivo activities and their mechanisms: a review Food Science and Human Wellness Diabetes Natural products Hypoglycemic effects Mechanism |
| title | Hypoglycemic natural products with in vivo activities and their mechanisms: a review |
| title_full | Hypoglycemic natural products with in vivo activities and their mechanisms: a review |
| title_fullStr | Hypoglycemic natural products with in vivo activities and their mechanisms: a review |
| title_full_unstemmed | Hypoglycemic natural products with in vivo activities and their mechanisms: a review |
| title_short | Hypoglycemic natural products with in vivo activities and their mechanisms: a review |
| title_sort | hypoglycemic natural products with in vivo activities and their mechanisms a review |
| topic | Diabetes Natural products Hypoglycemic effects Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000398 |
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