Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa
Orbital and ocular adnexal lymphomas are rare and represent around 1-2% of lymphomas and about 8% of the extranodal lymphomas. However, these entities represent the majority of orbital malignancies. Lymphomas of the ocular adnexal region are primary or secondary lymphomas, and the majority of them a...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/581856 |
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| author | Elham Vali Khojeini Benjamin H. Durham Mingyi Chen |
| author_facet | Elham Vali Khojeini Benjamin H. Durham Mingyi Chen |
| author_sort | Elham Vali Khojeini |
| collection | DOAJ |
| description | Orbital and ocular adnexal lymphomas are rare and represent around 1-2% of lymphomas and about 8% of the extranodal lymphomas. However, these entities represent the majority of orbital malignancies. Lymphomas of the ocular adnexal region are primary or secondary lymphomas, and the majority of them are composed of small, mature lymphocytes, which provide a large differential diagnosis. Thus, these entities are not easily distinguished from indolent lymphoid processes such as reactive lymphoid hyperplasia. Extranodal marginal zone lymphoma is the most common lymphoma in the ocular adnexal region. However, this entity cannot be distinguished from benign lymphoid proliferations or other lymphomas composed of small, mature lymphocytes by routine histopathology. We describe a 78-year-old man who presents with bilateral upper eyelid masses, which had been present and grew in size over the past twelve months prior to his presentation. A biopsy of the mass shows a monotonous population of small, mature lymphocytes. The immunohistochemical studies performed on the eyelid mass confirmed a monoclonal proliferation of B cells expressing cyclin-D1; therefore, a final diagnosis of mantle cell lymphoma was rendered. A literature review of mantle cell lymphoma with orbital and ocular adnexal involvement and the diagnostic pitfalls in this area of hematopathology are discussed. |
| format | Article |
| id | doaj-art-54d528638d354ef5b0f3627e7f49cf0c |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-54d528638d354ef5b0f3627e7f49cf0c2025-02-03T06:42:20ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/581856581856Mantle Cell Lymphoma and Involvement of the Orbit and Ocular AdnexaElham Vali Khojeini0Benjamin H. Durham1Mingyi Chen2Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, 4400 V Street, Sacramento, CA 95817, USADepartment of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, 4400 V Street, Sacramento, CA 95817, USADepartment of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, 4400 V Street, Sacramento, CA 95817, USAOrbital and ocular adnexal lymphomas are rare and represent around 1-2% of lymphomas and about 8% of the extranodal lymphomas. However, these entities represent the majority of orbital malignancies. Lymphomas of the ocular adnexal region are primary or secondary lymphomas, and the majority of them are composed of small, mature lymphocytes, which provide a large differential diagnosis. Thus, these entities are not easily distinguished from indolent lymphoid processes such as reactive lymphoid hyperplasia. Extranodal marginal zone lymphoma is the most common lymphoma in the ocular adnexal region. However, this entity cannot be distinguished from benign lymphoid proliferations or other lymphomas composed of small, mature lymphocytes by routine histopathology. We describe a 78-year-old man who presents with bilateral upper eyelid masses, which had been present and grew in size over the past twelve months prior to his presentation. A biopsy of the mass shows a monotonous population of small, mature lymphocytes. The immunohistochemical studies performed on the eyelid mass confirmed a monoclonal proliferation of B cells expressing cyclin-D1; therefore, a final diagnosis of mantle cell lymphoma was rendered. A literature review of mantle cell lymphoma with orbital and ocular adnexal involvement and the diagnostic pitfalls in this area of hematopathology are discussed.http://dx.doi.org/10.1155/2013/581856 |
| spellingShingle | Elham Vali Khojeini Benjamin H. Durham Mingyi Chen Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa Case Reports in Pathology |
| title | Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa |
| title_full | Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa |
| title_fullStr | Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa |
| title_full_unstemmed | Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa |
| title_short | Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa |
| title_sort | mantle cell lymphoma and involvement of the orbit and ocular adnexa |
| url | http://dx.doi.org/10.1155/2013/581856 |
| work_keys_str_mv | AT elhamvalikhojeini mantlecelllymphomaandinvolvementoftheorbitandocularadnexa AT benjaminhdurham mantlecelllymphomaandinvolvementoftheorbitandocularadnexa AT mingyichen mantlecelllymphomaandinvolvementoftheorbitandocularadnexa |