Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure
Few investigators have studied cognition over time in adults with heart failure (HF). A battery of neuropsychological tests was administered to 279 adults with chronic systolic or diastolic HF at baseline, three and six months. Growth mixture modeling (GMM) was used to model the measure anticipated...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/631075 |
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| author | Barbara Riegel Christopher S. Lee Dale Glaser Stephen T. Moelter |
| author_facet | Barbara Riegel Christopher S. Lee Dale Glaser Stephen T. Moelter |
| author_sort | Barbara Riegel |
| collection | DOAJ |
| description | Few investigators have studied cognition over time in adults with heart failure (HF). A battery of neuropsychological tests was administered to 279 adults with chronic systolic or diastolic HF at baseline, three and six months. Growth mixture modeling (GMM) was used to model the measure anticipated to be most sensitive, the digit symbol substitution task (DSST). We describe how and why the DSST patterns change over time. Other measures of cognition were examined to identify consistency with the DSST patterns. The sample was predominantly male (63.2%), Caucasian (62.7%), mean age 62 years. The best fit GMM revealed two trajectories of DSST scores: Average processing speed group (40.5%) and Below Average processing speed (59.9%). Neither group changed significantly over the six month study. Other measures of cognition were consistent with the DSST patterns. Factors significantly associated with increased odds of being in the Below Average processing speed group included older age, male gender, Non-Caucasian race, less education, higher ejection fraction, high comorbid burden, excessive daytime sleepiness, and higher BMI. As some of the factors related to cognitive impairment are modifiable, research is needed to identify interventions to preserve and improve cognition in these patients. |
| format | Article |
| id | doaj-art-54ceefa3efab40fcbaf13718569f63e9 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-54ceefa3efab40fcbaf13718569f63e92025-02-03T05:48:16ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/631075631075Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart FailureBarbara Riegel0Christopher S. Lee1Dale Glaser2Stephen T. Moelter3School of Nursing, University of Pennsylvania, 418 Curie Boulevard, Philadelphia, PA 19104-4217, USASchool of Nursing Portland Campus, 3455 SW US Veterans Hospital Road, SN-6N, Portland, OR 97239, USAGlaser Consulting, San Diego, CA, USAUniversity of the Sciences in Philadelphia, Behavioral and Social Sciences, 217 Kline Hall, 600 S. 43rd St, Philadelphia, PA 19104, USAFew investigators have studied cognition over time in adults with heart failure (HF). A battery of neuropsychological tests was administered to 279 adults with chronic systolic or diastolic HF at baseline, three and six months. Growth mixture modeling (GMM) was used to model the measure anticipated to be most sensitive, the digit symbol substitution task (DSST). We describe how and why the DSST patterns change over time. Other measures of cognition were examined to identify consistency with the DSST patterns. The sample was predominantly male (63.2%), Caucasian (62.7%), mean age 62 years. The best fit GMM revealed two trajectories of DSST scores: Average processing speed group (40.5%) and Below Average processing speed (59.9%). Neither group changed significantly over the six month study. Other measures of cognition were consistent with the DSST patterns. Factors significantly associated with increased odds of being in the Below Average processing speed group included older age, male gender, Non-Caucasian race, less education, higher ejection fraction, high comorbid burden, excessive daytime sleepiness, and higher BMI. As some of the factors related to cognitive impairment are modifiable, research is needed to identify interventions to preserve and improve cognition in these patients.http://dx.doi.org/10.1155/2012/631075 |
| spellingShingle | Barbara Riegel Christopher S. Lee Dale Glaser Stephen T. Moelter Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure Cardiology Research and Practice |
| title | Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure |
| title_full | Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure |
| title_fullStr | Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure |
| title_full_unstemmed | Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure |
| title_short | Patterns of Change in Cognitive Function over Six Months in Adults with Chronic Heart Failure |
| title_sort | patterns of change in cognitive function over six months in adults with chronic heart failure |
| url | http://dx.doi.org/10.1155/2012/631075 |
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