Phosphorescence-based O2 sensing reveals size-dependent survival and motility of metastatic prostate cancer cells in self-generated hypoxia

Phosphorescence-based O2 sensing reveals size-dependent survival and motility of metastatic prostate cancer cells in self-generated hypoxia

Summary: Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to vis...

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Bibliographic Details
Main Authors: Noreen Hosny, Kimberly Shen, Yihua Zhao, Junle Qu, Yusha Sun, George Butler, Sarah Amend, Emma U. Hammarlund, Robert Gatenby, Joel Brown, Kenneth J. Pienta, Trung V. Phan, Stephano Boyer-Paulet, Shengkai Li, Robert H. Austin
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Biotechnology
Technical aspects of cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005863
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