Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy
The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a s...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2012/920671 |
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| _version_ | 1850226428989145088 |
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| author | Defu Chen Huifen Zheng Zhiyong Huang Huiyun Lin Zhidong Ke Shusen Xie Buhong Li |
| author_facet | Defu Chen Huifen Zheng Zhiyong Huang Huiyun Lin Zhidong Ke Shusen Xie Buhong Li |
| author_sort | Defu Chen |
| collection | DOAJ |
| description | The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate. |
| format | Article |
| id | doaj-art-54c6019d29f54cb7ad7b4b87b61d26d4 |
| institution | OA Journals |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-54c6019d29f54cb7ad7b4b87b61d26d42025-08-20T02:05:04ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2012-01-01201210.1155/2012/920671920671Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic TherapyDefu Chen0Huifen Zheng1Zhiyong Huang2Huiyun Lin3Zhidong Ke4Shusen Xie5Buhong Li6Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, ChinaThe aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.http://dx.doi.org/10.1155/2012/920671 |
| spellingShingle | Defu Chen Huifen Zheng Zhiyong Huang Huiyun Lin Zhidong Ke Shusen Xie Buhong Li Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy International Journal of Photoenergy |
| title | Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy |
| title_full | Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy |
| title_fullStr | Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy |
| title_full_unstemmed | Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy |
| title_short | Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy |
| title_sort | light emitting diode based illumination system for in vitro photodynamic therapy |
| url | http://dx.doi.org/10.1155/2012/920671 |
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