Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries?
Background and Objective. Despite the extensive reporting of eosinophilic esophagitis (EoE) from industrialized developed countries, reports from developing countries are rare. The aim of our study was to determine the epidemiological, clinical, and endoscopic features of EoE and response to therapy...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/526037 |
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| author | Abdulrahman Al-Hussaini Toufic Semaan Imad El Hag |
| author_facet | Abdulrahman Al-Hussaini Toufic Semaan Imad El Hag |
| author_sort | Abdulrahman Al-Hussaini |
| collection | DOAJ |
| description | Background and Objective. Despite the extensive reporting of eosinophilic esophagitis (EoE) from industrialized developed countries, reports from developing countries are rare. The aim of our study was to determine the epidemiological, clinical, and endoscopic features of EoE and response to therapy in children and adults from a developing country, Saudi Arabia. Methods. We identified patients diagnosed with EoE in our center from 2004 to 2011. EoE was defined as esophageal mucosal infiltration with a peak eosinophil count ≥15 eosinophils/high-powered field. Results. Forty-five patients were diagnosed with EoE (37 children and 8 adults; 36 males; median age 10.5 years, range from 1–37 years). Feeding difficulty, vomiting/regurgitation, and failure to thrive predominated in young children, whereas dysphagia and food impactions predominated in older children and adults. Allergy testing revealed food sensitization in 12 of 15 patients (80%); 3 responded to elemental formula, while 8 failed to respond to dietary manipulation after the allergy testing. Thirty-nine patients achieved remission by swallowed inhaled fluticasone. The majority of patients experienced a recurrence of symptoms upon the discontinuation of fluticasone. Conclusion. Our data indicate that EoE is increasingly recognized in Saudi Arabia and show many similarities to data from North America and Europe. |
| format | Article |
| id | doaj-art-54c5567374c64d7f919ce7f49172c285 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-54c5567374c64d7f919ce7f49172c2852025-02-03T00:59:51ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/526037526037Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries?Abdulrahman Al-Hussaini0Toufic Semaan1Imad El Hag2University of King Saud bin Abdulaziz for Health Sciences, Children's Hospital, King Fahad Medical City, P.O. Box 59046, Riyadh, Saudi ArabiaDepartment of Medicine, King Saud Medical City, P.O. Box 7855, Riyadh, Saudi ArabiaDepartment of Pathology, Prince Sultan Medical City, P.O. Box 7855, Riyadh 111107, Saudi ArabiaBackground and Objective. Despite the extensive reporting of eosinophilic esophagitis (EoE) from industrialized developed countries, reports from developing countries are rare. The aim of our study was to determine the epidemiological, clinical, and endoscopic features of EoE and response to therapy in children and adults from a developing country, Saudi Arabia. Methods. We identified patients diagnosed with EoE in our center from 2004 to 2011. EoE was defined as esophageal mucosal infiltration with a peak eosinophil count ≥15 eosinophils/high-powered field. Results. Forty-five patients were diagnosed with EoE (37 children and 8 adults; 36 males; median age 10.5 years, range from 1–37 years). Feeding difficulty, vomiting/regurgitation, and failure to thrive predominated in young children, whereas dysphagia and food impactions predominated in older children and adults. Allergy testing revealed food sensitization in 12 of 15 patients (80%); 3 responded to elemental formula, while 8 failed to respond to dietary manipulation after the allergy testing. Thirty-nine patients achieved remission by swallowed inhaled fluticasone. The majority of patients experienced a recurrence of symptoms upon the discontinuation of fluticasone. Conclusion. Our data indicate that EoE is increasingly recognized in Saudi Arabia and show many similarities to data from North America and Europe.http://dx.doi.org/10.1155/2013/526037 |
| spellingShingle | Abdulrahman Al-Hussaini Toufic Semaan Imad El Hag Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? Gastroenterology Research and Practice |
| title | Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? |
| title_full | Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? |
| title_fullStr | Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? |
| title_full_unstemmed | Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? |
| title_short | Eosinophilic Esophagitis in a Developing Country: Is It Different from Developed Countries? |
| title_sort | eosinophilic esophagitis in a developing country is it different from developed countries |
| url | http://dx.doi.org/10.1155/2013/526037 |
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