The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression
Abstract RNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating RNA metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation in eukaryotic RNA, influences cancer pat...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.70026 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850032183935238144 |
|---|---|
| author | Zhuoran Gu Libin Zou Xinjian Pan Yang Yu Yongqiang Liu Zhijin Zhang Ji Liu Shiyu Mao Junfeng Zhang Changcheng Guo Wei Li Jiang Geng Wentao Zhang Xudong Yao Bing Shen |
| author_facet | Zhuoran Gu Libin Zou Xinjian Pan Yang Yu Yongqiang Liu Zhijin Zhang Ji Liu Shiyu Mao Junfeng Zhang Changcheng Guo Wei Li Jiang Geng Wentao Zhang Xudong Yao Bing Shen |
| author_sort | Zhuoran Gu |
| collection | DOAJ |
| description | Abstract RNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating RNA metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation in eukaryotic RNA, influences cancer pathogenesis and progression. NAT10 is the only writer of ac4C and catalyzes acetyl transfer on targeted RNA, and ac4C helps to improve the stability and translational efficiency of ac4C‐modified RNA. NAT10 is highly expressed and associated with poor prognosis in pan‐cancers. Based on its molecular mechanism and biological functions, ac4C is a central factor in tumorigenesis, tumor progression, drug resistance, and tumor immune escape. Despite the increasing focus on ac4C, the specific regulatory mechanisms of ac4C in cancer remain elusive. The present review thoroughly analyzes the current knowledge on NAT10‐mediated ac4C modification in cancer, highlighting its broad regulatory influence on targeted gene expression and tumor biology. This review also summarizes the limitations and perspectives of current research on NAT10 and ac4C in cancer, to identify new therapeutic targets and advance cancer treatment strategies. |
| format | Article |
| id | doaj-art-54c4a92227d242d4a14739bc3ff7c773 |
| institution | DOAJ |
| issn | 2688-2663 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-54c4a92227d242d4a14739bc3ff7c7732025-08-20T02:58:44ZengWileyMedComm2688-26632024-12-01512n/an/a10.1002/mco2.70026The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progressionZhuoran Gu0Libin Zou1Xinjian Pan2Yang Yu3Yongqiang Liu4Zhijin Zhang5Ji Liu6Shiyu Mao7Junfeng Zhang8Changcheng Guo9Wei Li10Jiang Geng11Wentao Zhang12Xudong Yao13Bing Shen14Department of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Urology Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai ChinaAbstract RNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating RNA metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation in eukaryotic RNA, influences cancer pathogenesis and progression. NAT10 is the only writer of ac4C and catalyzes acetyl transfer on targeted RNA, and ac4C helps to improve the stability and translational efficiency of ac4C‐modified RNA. NAT10 is highly expressed and associated with poor prognosis in pan‐cancers. Based on its molecular mechanism and biological functions, ac4C is a central factor in tumorigenesis, tumor progression, drug resistance, and tumor immune escape. Despite the increasing focus on ac4C, the specific regulatory mechanisms of ac4C in cancer remain elusive. The present review thoroughly analyzes the current knowledge on NAT10‐mediated ac4C modification in cancer, highlighting its broad regulatory influence on targeted gene expression and tumor biology. This review also summarizes the limitations and perspectives of current research on NAT10 and ac4C in cancer, to identify new therapeutic targets and advance cancer treatment strategies.https://doi.org/10.1002/mco2.70026cancerepitranscriptomeN4‐acetylation (ac4C)N‐acetyltransferase 10 (NAT10)RNA modification |
| spellingShingle | Zhuoran Gu Libin Zou Xinjian Pan Yang Yu Yongqiang Liu Zhijin Zhang Ji Liu Shiyu Mao Junfeng Zhang Changcheng Guo Wei Li Jiang Geng Wentao Zhang Xudong Yao Bing Shen The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression MedComm cancer epitranscriptome N4‐acetylation (ac4C) N‐acetyltransferase 10 (NAT10) RNA modification |
| title | The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression |
| title_full | The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression |
| title_fullStr | The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression |
| title_full_unstemmed | The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression |
| title_short | The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression |
| title_sort | role and mechanism of nat10 mediated ac4c modification in tumor development and progression |
| topic | cancer epitranscriptome N4‐acetylation (ac4C) N‐acetyltransferase 10 (NAT10) RNA modification |
| url | https://doi.org/10.1002/mco2.70026 |
| work_keys_str_mv | AT zhuorangu theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT libinzou theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT xinjianpan theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT yangyu theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT yongqiangliu theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT zhijinzhang theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT jiliu theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT shiyumao theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT junfengzhang theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT changchengguo theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT weili theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT jianggeng theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT wentaozhang theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT xudongyao theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT bingshen theroleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT zhuorangu roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT libinzou roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT xinjianpan roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT yangyu roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT yongqiangliu roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT zhijinzhang roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT jiliu roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT shiyumao roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT junfengzhang roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT changchengguo roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT weili roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT jianggeng roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT wentaozhang roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT xudongyao roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression AT bingshen roleandmechanismofnat10mediatedac4cmodificationintumordevelopmentandprogression |