Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach

Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach

3,4,5-Trihydroxybiphenyl (THB) is a naturally occurring compound derived from Sorbus pohuashanensis, primarily reported for its antifungal activity. However, its potential to inhibit α-glucosidase remains unclear. In this study, we assessed the inhibitory effects of THB on α-glucosidase and explored...

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Bibliographic Details
Main Authors: Ruofan Guo, Guohua Yu, Yuan Li, Youyou Wang, Huixia Fan, Shuo Zhang, Chen Wang, Junhui Zhou, Jian Yang, Feng Gao, Zhiqiang Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
α-glucosidase
inhibition activity
interaction mechanism
postprandial blood glucose
diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1584264/full
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