Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq
Chronic social defeat stress leads to the development of anxiety- and depression-like states in male mice and is accompanied by numerous molecular changes in brain. The influence of 21-day period of social stress on ribosomal gene expression in five brain regions was studied using the RNA-Seq databa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3289187 |
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| author | Dmitry A. Smagin Irina L. Kovalenko Anna G. Galyamina Anatoly O. Bragin Yuriy L. Orlov Natalia N. Kudryavtseva |
| author_facet | Dmitry A. Smagin Irina L. Kovalenko Anna G. Galyamina Anatoly O. Bragin Yuriy L. Orlov Natalia N. Kudryavtseva |
| author_sort | Dmitry A. Smagin |
| collection | DOAJ |
| description | Chronic social defeat stress leads to the development of anxiety- and depression-like states in male mice and is accompanied by numerous molecular changes in brain. The influence of 21-day period of social stress on ribosomal gene expression in five brain regions was studied using the RNA-Seq database. Most Rps, Rpl, Mprs, and Mprl genes were upregulated in the hypothalamus and downregulated in the hippocampus, which may indicate ribosomal dysfunction following chronic social defeat stress. There were no differentially expressed ribosomal genes in the ventral tegmental area, midbrain raphe nuclei, or striatum. This approach may be used to identify a pharmacological treatment of ribosome biogenesis abnormalities in the brain of patients with “ribosomopathies.” |
| format | Article |
| id | doaj-art-54c1fb8c405041a9b71766fb215f0b60 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-54c1fb8c405041a9b71766fb215f0b602025-02-03T05:59:07ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/32891873289187Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-SeqDmitry A. Smagin0Irina L. Kovalenko1Anna G. Galyamina2Anatoly O. Bragin3Yuriy L. Orlov4Natalia N. Kudryavtseva5Modeling of Neuropathology Laboratory, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaModeling of Neuropathology Laboratory, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaModeling of Neuropathology Laboratory, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaLaboratory of Behavioral Neuroinformatics, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaLaboratory of Behavioral Neuroinformatics, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaModeling of Neuropathology Laboratory, Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk 630090, RussiaChronic social defeat stress leads to the development of anxiety- and depression-like states in male mice and is accompanied by numerous molecular changes in brain. The influence of 21-day period of social stress on ribosomal gene expression in five brain regions was studied using the RNA-Seq database. Most Rps, Rpl, Mprs, and Mprl genes were upregulated in the hypothalamus and downregulated in the hippocampus, which may indicate ribosomal dysfunction following chronic social defeat stress. There were no differentially expressed ribosomal genes in the ventral tegmental area, midbrain raphe nuclei, or striatum. This approach may be used to identify a pharmacological treatment of ribosome biogenesis abnormalities in the brain of patients with “ribosomopathies.”http://dx.doi.org/10.1155/2016/3289187 |
| spellingShingle | Dmitry A. Smagin Irina L. Kovalenko Anna G. Galyamina Anatoly O. Bragin Yuriy L. Orlov Natalia N. Kudryavtseva Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq Neural Plasticity |
| title | Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq |
| title_full | Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq |
| title_fullStr | Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq |
| title_full_unstemmed | Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq |
| title_short | Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq |
| title_sort | dysfunction in ribosomal gene expression in the hypothalamus and hippocampus following chronic social defeat stress in male mice as revealed by rna seq |
| url | http://dx.doi.org/10.1155/2016/3289187 |
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