Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3425908 |
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| author | Ossama Khalaf Johannes Gräff |
| author_facet | Ossama Khalaf Johannes Gräff |
| author_sort | Ossama Khalaf |
| collection | DOAJ |
| description | Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last. |
| format | Article |
| id | doaj-art-54bf5664f68842a7848d50cad192fb91 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-54bf5664f68842a7848d50cad192fb912025-02-03T07:24:52ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/34259083425908Structural, Synaptic, and Epigenetic Dynamics of Enduring MemoriesOssama Khalaf0Johannes Gräff1Laboratory of Neuroepigenetics, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Neuroepigenetics, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandOur memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last.http://dx.doi.org/10.1155/2016/3425908 |
| spellingShingle | Ossama Khalaf Johannes Gräff Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories Neural Plasticity |
| title | Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories |
| title_full | Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories |
| title_fullStr | Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories |
| title_full_unstemmed | Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories |
| title_short | Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories |
| title_sort | structural synaptic and epigenetic dynamics of enduring memories |
| url | http://dx.doi.org/10.1155/2016/3425908 |
| work_keys_str_mv | AT ossamakhalaf structuralsynapticandepigeneticdynamicsofenduringmemories AT johannesgraff structuralsynapticandepigeneticdynamicsofenduringmemories |