Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants
Abstract Feeding intolerance (FI) is a common clinical problem in very preterm infants (VPIs) and it increases the risk for adverse outcomes. The value of regional tissue oxygen saturation in predicting FI remains unclear. A total of 57 VPIs were involved in this study, and the regional splanchnic a...
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Nature Portfolio
2025-03-01
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| author | Jianyun Chen Xi Fan Shanshan He Zhiying Lin Zhiwen Su Fan Wu |
| author_facet | Jianyun Chen Xi Fan Shanshan He Zhiying Lin Zhiwen Su Fan Wu |
| author_sort | Jianyun Chen |
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| description | Abstract Feeding intolerance (FI) is a common clinical problem in very preterm infants (VPIs) and it increases the risk for adverse outcomes. The value of regional tissue oxygen saturation in predicting FI remains unclear. A total of 57 VPIs were involved in this study, and the regional splanchnic and cerebral tissue oxygen saturation during minimal enteral feeding in the first 3 days after birth was monitored and analyzed. Compared with the feeding tolerance (FT) group, the FI group had a smaller gestational age, lower birth weight, and higher rate of maternal hypertensive disorders in pregnancy. Even more, the FI group had lower regional splanchnic tissue oxygen saturation and lower splanchnic-cerebral oxygenation ratio (SCOR) at the 1st hour and 2nd hour after feeding on the 3rd postnatal day than the FT group (P < 0.05). Multivariate logistic regression analysis showed that increased gestational age and elevated SCOR at the 2nd hour after feeding on the 3rd postnatal day reduced the risk for FI (P < 0.05). The areas under the curve (AUCs) of gestational age, SCOR at the 2nd hour after feeding on the 3rd postnatal day and their combination in predicting FT were 0.745 (95%CI 0.616 ~ 0.874), 0.756 (95%CI 0.628 ~ 0.883) and 0.820 (95%CI 0.710 ~ 0.929), respectively. |
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| spelling | doaj-art-54ac7c17c58a4dbda2ddd510bd13f1ac2025-08-20T03:02:19ZengNature PortfolioScientific Reports2045-23222025-03-011511910.1038/s41598-025-92185-4Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infantsJianyun Chen0Xi Fan1Shanshan He2Zhiying Lin3Zhiwen Su4Fan Wu5Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital, Guangzhou Medical UniversityAbstract Feeding intolerance (FI) is a common clinical problem in very preterm infants (VPIs) and it increases the risk for adverse outcomes. The value of regional tissue oxygen saturation in predicting FI remains unclear. A total of 57 VPIs were involved in this study, and the regional splanchnic and cerebral tissue oxygen saturation during minimal enteral feeding in the first 3 days after birth was monitored and analyzed. Compared with the feeding tolerance (FT) group, the FI group had a smaller gestational age, lower birth weight, and higher rate of maternal hypertensive disorders in pregnancy. Even more, the FI group had lower regional splanchnic tissue oxygen saturation and lower splanchnic-cerebral oxygenation ratio (SCOR) at the 1st hour and 2nd hour after feeding on the 3rd postnatal day than the FT group (P < 0.05). Multivariate logistic regression analysis showed that increased gestational age and elevated SCOR at the 2nd hour after feeding on the 3rd postnatal day reduced the risk for FI (P < 0.05). The areas under the curve (AUCs) of gestational age, SCOR at the 2nd hour after feeding on the 3rd postnatal day and their combination in predicting FT were 0.745 (95%CI 0.616 ~ 0.874), 0.756 (95%CI 0.628 ~ 0.883) and 0.820 (95%CI 0.710 ~ 0.929), respectively.https://doi.org/10.1038/s41598-025-92185-4Feeding intoleranceRegional tissue oxygen saturationPreterm infantNear-infrared spectroscopyMinimal enteral feeding |
| spellingShingle | Jianyun Chen Xi Fan Shanshan He Zhiying Lin Zhiwen Su Fan Wu Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants Scientific Reports Feeding intolerance Regional tissue oxygen saturation Preterm infant Near-infrared spectroscopy Minimal enteral feeding |
| title | Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| title_full | Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| title_fullStr | Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| title_full_unstemmed | Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| title_short | Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| title_sort | regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants |
| topic | Feeding intolerance Regional tissue oxygen saturation Preterm infant Near-infrared spectroscopy Minimal enteral feeding |
| url | https://doi.org/10.1038/s41598-025-92185-4 |
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