CXCL14 drives age-related intervertebral disc degeneration via NF-κB pathway activation in a multiomic study

CXCL14 drives age-related intervertebral disc degeneration via NF-κB pathway activation in a multiomic study

Abstract Intervertebral disc degeneration (IDD), a common cause of chronic low back pain, strongly impacts daily life. Although previous studies have identified certain biomarkers indicating IDD, comprehensive analyses that integrate transcriptomic and proteomic data to elucidate age-related changes...

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Bibliographic Details
Main Authors: Tianle Zhou, Tonghui Zhang, Qiwang He, Zhiwen Zhang, Yong Huang, Zijun Chen, Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Transcriptomic
Proteomic
Intervertebral disc degeneration
CXCL14
Online Access:https://doi.org/10.1038/s41598-025-10998-9
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