PD-L1 expression predicts the efficacy of PD-1 blockade plus chemotherapy versus chemotherapy alone in treatment-naïve advanced or metastatic gastric cancer: a pooled analysis of reconstructed individual patient-level data from two randomized trials

PD-L1 expression predicts the efficacy of PD-1 blockade plus chemotherapy versus chemotherapy alone in treatment-naïve advanced or metastatic gastric cancer: a pooled analysis of reconstructed individual patient-level data from two randomized trials

BackgroundChemotherapy alone exhibits suboptimal efficacy in patients with treatment-naïve advanced gastric cancer (GC). Randomized controlled trials (RCTs) have demonstrated that combining Programmed Cell Death Protein-1 (PD-1) blockade with chemotherapy significantly improves overall survival (OS)...

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Bibliographic Details
Main Authors: Wei Zhou, Zeng-Zhi Cai, Zhuolin Fan, Xu Zheng, Yu-Tong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
advanced gastric cancer
programmed cell death Protein-1 blockade
chemotherapy
programmed cell death-ligand 1 expression
combined positive score
randomized controlled trials
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1636288/full
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