Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context
Summary: China accounts for 1/5 of the global population and China faces a particularly heavy dementia burden due to its rapidly ageing population. Unique historical events, genetic background, sociocultural factors, lifestyle, and the COVID-19 pandemic further influence cognitive outcomes in the Ch...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | The Lancet Regional Health. Western Pacific |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606525000021 |
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| author | Xiaowen Zhou Zhenxu Xiao Wanqing Wu Yuntao Chen Changzheng Yuan Yue Leng Yao Yao Qianhua Zhao Albert Hofman Eric Brunner Ding Ding |
| author_facet | Xiaowen Zhou Zhenxu Xiao Wanqing Wu Yuntao Chen Changzheng Yuan Yue Leng Yao Yao Qianhua Zhao Albert Hofman Eric Brunner Ding Ding |
| author_sort | Xiaowen Zhou |
| collection | DOAJ |
| description | Summary: China accounts for 1/5 of the global population and China faces a particularly heavy dementia burden due to its rapidly ageing population. Unique historical events, genetic background, sociocultural factors, lifestyle, and the COVID-19 pandemic further influence cognitive outcomes in the Chinese population. We searched PubMed, Web of Science, and Embase for community-based cohort studies related to dementia in the Chinese population, and summarized the characteristics, methodologies, and major findings published over the last 25 years from 39 cohorts. We identified critical research gaps and propose future directions, including enhancing sample representativeness, investigating China-specific risk factors, expanding exposure measurements to the whole life-span, collecting objective data, conducting administer-friendly domain-specific cognitive assessments, adopting pathological diagnostic criteria, standardizing biobank construction, verifying multi-modal biomarkers, examining social and genetic-environmental aspects, and monitoring post-COVID cognitive health, to approach high quality of dementia studies that can provide solid evidence to policy making and promote global brain health research. |
| format | Article |
| id | doaj-art-54a206337e9947f28d78ae77db3ab465 |
| institution | Kabale University |
| issn | 2666-6065 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj-art-54a206337e9947f28d78ae77db3ab4652025-01-22T05:44:10ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652025-02-0155101465Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in contextXiaowen Zhou0Zhenxu Xiao1Wanqing Wu2Yuntao Chen3Changzheng Yuan4Yue Leng5Yao Yao6Qianhua Zhao7Albert Hofman8Eric Brunner9Ding Ding10Institute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, ChinaInstitute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, ChinaInstitute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, SwedenDivision of Psychiatry, Faculty of Brain Science, UCL, London, UKSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USADepartment of Psychiatry and Behavioural Sciences, University of California, San Francisco, USAChina Center for Health Development Studies, School of Public Health, Peking University, Beijing, ChinaInstitute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USAInstitute of Epidemiology and Health Care, UCL, London, UKInstitute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; Corresponding author. Institute of Neurology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Rd., Shanghai, 200040, China.Summary: China accounts for 1/5 of the global population and China faces a particularly heavy dementia burden due to its rapidly ageing population. Unique historical events, genetic background, sociocultural factors, lifestyle, and the COVID-19 pandemic further influence cognitive outcomes in the Chinese population. We searched PubMed, Web of Science, and Embase for community-based cohort studies related to dementia in the Chinese population, and summarized the characteristics, methodologies, and major findings published over the last 25 years from 39 cohorts. We identified critical research gaps and propose future directions, including enhancing sample representativeness, investigating China-specific risk factors, expanding exposure measurements to the whole life-span, collecting objective data, conducting administer-friendly domain-specific cognitive assessments, adopting pathological diagnostic criteria, standardizing biobank construction, verifying multi-modal biomarkers, examining social and genetic-environmental aspects, and monitoring post-COVID cognitive health, to approach high quality of dementia studies that can provide solid evidence to policy making and promote global brain health research.http://www.sciencedirect.com/science/article/pii/S2666606525000021DementiaCommunity-basedCohortChinese populationCognitive impairment |
| spellingShingle | Xiaowen Zhou Zhenxu Xiao Wanqing Wu Yuntao Chen Changzheng Yuan Yue Leng Yao Yao Qianhua Zhao Albert Hofman Eric Brunner Ding Ding Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context The Lancet Regional Health. Western Pacific Dementia Community-based Cohort Chinese population Cognitive impairment |
| title | Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context |
| title_full | Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context |
| title_fullStr | Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context |
| title_full_unstemmed | Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context |
| title_short | Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context |
| title_sort | closing the gap in dementia research by community based cohort studies in the chinese populationresearch in context |
| topic | Dementia Community-based Cohort Chinese population Cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S2666606525000021 |
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