SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021
Objective To estimate the degree of SARS-CoV-2 transmission among healthcare workers (HCWs) and general population in Kita region of Mali.Design Routine surveillance in 12 health facilities, HCWs serosurvey in five health facilities and community serosurvey in 16 villages in or near Kita town, Mali....
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e060367.full |
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| author | Ulla Ashorn Per Ashorn Nigel Klein Samba O Sow Camilla Ducker Elaine Cloutman-Green Dagmar Alber Fadima Cheick Haidara Juho Luoma Laura Adubra Henry Badji Fatoumata Diallo Rikhard Ihamuotila Owen Martell Uma U Onwuchekwa Oumar Samaké Awa Traore Kevin Wilson Yue-Mei Fan |
| author_facet | Ulla Ashorn Per Ashorn Nigel Klein Samba O Sow Camilla Ducker Elaine Cloutman-Green Dagmar Alber Fadima Cheick Haidara Juho Luoma Laura Adubra Henry Badji Fatoumata Diallo Rikhard Ihamuotila Owen Martell Uma U Onwuchekwa Oumar Samaké Awa Traore Kevin Wilson Yue-Mei Fan |
| author_sort | Ulla Ashorn |
| collection | DOAJ |
| description | Objective To estimate the degree of SARS-CoV-2 transmission among healthcare workers (HCWs) and general population in Kita region of Mali.Design Routine surveillance in 12 health facilities, HCWs serosurvey in five health facilities and community serosurvey in 16 villages in or near Kita town, Mali.Setting Kita region, western Mali; local health centres around the central (regional) referral health centre.Participants Patients in routine surveillance, HCWs in local health centres and community members of all ages in populations associated with study health centres.Main outcome measures Seropositivity of ELISA test detecting SARS-CoV-2-specific total antibodies and real-time RT-PCR confirmed SARS-CoV-2 infection.Results From 2392 routine surveillance samples, 68 (2.8%, 95% CI: 2.2% to 3.6%) tested positive for SARS-CoV-2 by RT-PCR. The monthly positivity rate was 0% in June–August 2020 and gradually increased to 6% by December 2020 and 6.2% by January 2021, then declined to 5.5%, 3.3%, 3.6% and 0.8% in February, March, April and May 2021, respectively. From 397 serum samples collected from 113 HCWs, 175 (44.1%, 95% CI: 39.1% to 49.1%) were positive for SARS-CoV-2 antibodies. The monthly seroprevalence was around 10% from September to November 2020 and increased to over 40% from December 2020 to May 2021. For community serosurvey in December 2020, overall seroprevalence of SARS-CoV-2 antibodies was 27.7%. The highest age-stratified seroprevalence was observed in participants aged 60–69 years (45.5%, 95% CI: 32.3% to 58.6%). The lowest was in children aged 0–9 years (14.0%, 95% CI: 7.4% to 20.6%).Conclusions SARS-CoV-2 in rural Mali is much more widespread than assumed by national testing data and particularly in the older population and frontline HCWs. The observation is contrary to the widely expressed view, based on limited data, that COVID-19 infection rates were lower in 2020–2021 in West Africa than in other settings. |
| format | Article |
| id | doaj-art-54826fdd32c94519a6113ee8f4b7bf44 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-54826fdd32c94519a6113ee8f4b7bf442025-02-01T12:15:11ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-060367SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021Ulla Ashorn0Per Ashorn1Nigel Klein2Samba O Sow3Camilla Ducker4Elaine Cloutman-Green5Dagmar Alber6Fadima Cheick Haidara7Juho Luoma8Laura Adubra9Henry Badji10Fatoumata Diallo11Rikhard Ihamuotila12Owen Martell13Uma U Onwuchekwa14Oumar Samaké15Awa Traore16Kevin Wilson17Yue-Mei Fan1813 Centre for Child Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCenter for Child Health Research, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Pirkanmaa, FinlandUniversity College London, London, UK2 Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, MaliTro Da Ltd, London, UKGreat Ormond Street Institute of Child Health, University College London, London, UKGreat Ormond Street Institute of Child Health, University College London, London, UK2 Centre pour le Développement des Vaccins, Bamako, MaliCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCenter for Vaccine Development–Mali, Bamako, MaliCenter for Vaccine Development–Mali, Bamako, MaliCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandTro Da Ltd, London, UKCenter for Vaccine Development–Mali, Bamako, MaliCenter for Vaccine Development–Mali, Bamako, MaliCenter for Vaccine Development–Mali, Bamako, MaliCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandObjective To estimate the degree of SARS-CoV-2 transmission among healthcare workers (HCWs) and general population in Kita region of Mali.Design Routine surveillance in 12 health facilities, HCWs serosurvey in five health facilities and community serosurvey in 16 villages in or near Kita town, Mali.Setting Kita region, western Mali; local health centres around the central (regional) referral health centre.Participants Patients in routine surveillance, HCWs in local health centres and community members of all ages in populations associated with study health centres.Main outcome measures Seropositivity of ELISA test detecting SARS-CoV-2-specific total antibodies and real-time RT-PCR confirmed SARS-CoV-2 infection.Results From 2392 routine surveillance samples, 68 (2.8%, 95% CI: 2.2% to 3.6%) tested positive for SARS-CoV-2 by RT-PCR. The monthly positivity rate was 0% in June–August 2020 and gradually increased to 6% by December 2020 and 6.2% by January 2021, then declined to 5.5%, 3.3%, 3.6% and 0.8% in February, March, April and May 2021, respectively. From 397 serum samples collected from 113 HCWs, 175 (44.1%, 95% CI: 39.1% to 49.1%) were positive for SARS-CoV-2 antibodies. The monthly seroprevalence was around 10% from September to November 2020 and increased to over 40% from December 2020 to May 2021. For community serosurvey in December 2020, overall seroprevalence of SARS-CoV-2 antibodies was 27.7%. The highest age-stratified seroprevalence was observed in participants aged 60–69 years (45.5%, 95% CI: 32.3% to 58.6%). The lowest was in children aged 0–9 years (14.0%, 95% CI: 7.4% to 20.6%).Conclusions SARS-CoV-2 in rural Mali is much more widespread than assumed by national testing data and particularly in the older population and frontline HCWs. The observation is contrary to the widely expressed view, based on limited data, that COVID-19 infection rates were lower in 2020–2021 in West Africa than in other settings.https://bmjopen.bmj.com/content/12/6/e060367.full |
| spellingShingle | Ulla Ashorn Per Ashorn Nigel Klein Samba O Sow Camilla Ducker Elaine Cloutman-Green Dagmar Alber Fadima Cheick Haidara Juho Luoma Laura Adubra Henry Badji Fatoumata Diallo Rikhard Ihamuotila Owen Martell Uma U Onwuchekwa Oumar Samaké Awa Traore Kevin Wilson Yue-Mei Fan SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 BMJ Open |
| title | SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 |
| title_full | SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 |
| title_fullStr | SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 |
| title_full_unstemmed | SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 |
| title_short | SARS-CoV-2 infection and antibody seroprevalence in routine surveillance patients, healthcare workers and general population in Kita region, Mali: an observational study 2020–2021 |
| title_sort | sars cov 2 infection and antibody seroprevalence in routine surveillance patients healthcare workers and general population in kita region mali an observational study 2020 2021 |
| url | https://bmjopen.bmj.com/content/12/6/e060367.full |
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