Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics
The rapid worldwide spread of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviru...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/6941735 |
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| author | Túlio De Lima Campos Ricardo Durães-Carvalho Antonio Mauro Rezende Otávio Valério de Carvalho Alain Kohl Gabriel Luz Wallau Lindomar José Pena |
| author_facet | Túlio De Lima Campos Ricardo Durães-Carvalho Antonio Mauro Rezende Otávio Valério de Carvalho Alain Kohl Gabriel Luz Wallau Lindomar José Pena |
| author_sort | Túlio De Lima Campos |
| collection | DOAJ |
| description | The rapid worldwide spread of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. Understanding how the virus circulates and moves from one country to another is of paramount importance to assist government and health officials in anticipating future epidemics, as well as to take steps to help control or mitigate the spread of the virus. Through the analyses of the sequences of arbovirus genomes collected at different locations over time, we identified patterns of accumulated mutations, being able to trace routes of dispersion of these viruses. Here, we applied robust phylogenomic methods to trace the evolutionary dynamics of these arboviruses with special focus on Brazil, the epicenter of these triple epidemics. Our results show that CHIKV, DENV-1–4, and ZIKV followed a similar path prior to their first introductions into the mainland Americas, underscoring the need for systematic arboviral surveillance at major entry points of human population movement between countries such as airports and seaports. |
| format | Article |
| id | doaj-art-54800a75c48840ef99fe3f0aa4154158 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-54800a75c48840ef99fe3f0aa41541582025-02-03T01:07:29ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/69417356941735Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale PhylogenomicsTúlio De Lima Campos0Ricardo Durães-Carvalho1Antonio Mauro Rezende2Otávio Valério de Carvalho3Alain Kohl4Gabriel Luz Wallau5Lindomar José Pena6Bioinformatics Core Facility, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilDepartment of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilDepartment of Microbiology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilDepartment of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilMRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UKDepartment of Entomology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilDepartment of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife PE, BrazilThe rapid worldwide spread of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. Understanding how the virus circulates and moves from one country to another is of paramount importance to assist government and health officials in anticipating future epidemics, as well as to take steps to help control or mitigate the spread of the virus. Through the analyses of the sequences of arbovirus genomes collected at different locations over time, we identified patterns of accumulated mutations, being able to trace routes of dispersion of these viruses. Here, we applied robust phylogenomic methods to trace the evolutionary dynamics of these arboviruses with special focus on Brazil, the epicenter of these triple epidemics. Our results show that CHIKV, DENV-1–4, and ZIKV followed a similar path prior to their first introductions into the mainland Americas, underscoring the need for systematic arboviral surveillance at major entry points of human population movement between countries such as airports and seaports.http://dx.doi.org/10.1155/2018/6941735 |
| spellingShingle | Túlio De Lima Campos Ricardo Durães-Carvalho Antonio Mauro Rezende Otávio Valério de Carvalho Alain Kohl Gabriel Luz Wallau Lindomar José Pena Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics International Journal of Genomics |
| title | Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics |
| title_full | Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics |
| title_fullStr | Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics |
| title_full_unstemmed | Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics |
| title_short | Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics |
| title_sort | revisiting key entry routes of human epidemic arboviruses into the mainland americas through large scale phylogenomics |
| url | http://dx.doi.org/10.1155/2018/6941735 |
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