Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards
Introduction Oxygen is an essential medicine for children and adults. The current systems for its delivery can be expensive and unreliable in settings where oxygen is most needed. FREO2 Foundation Australia has developed an integrated oxygen system, driven by a mains-powered oxygen concentrator, wit...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e054642.full |
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| author | Graham Moore Hamish Graham Rami Subhi Sheillah Bagayana Joseph Mugerwa David Peake Eleanor Nakintu Daniel Murokora Roger Rassool Marc Sklar Bryn Sobott |
| author_facet | Graham Moore Hamish Graham Rami Subhi Sheillah Bagayana Joseph Mugerwa David Peake Eleanor Nakintu Daniel Murokora Roger Rassool Marc Sklar Bryn Sobott |
| author_sort | Graham Moore |
| collection | DOAJ |
| description | Introduction Oxygen is an essential medicine for children and adults. The current systems for its delivery can be expensive and unreliable in settings where oxygen is most needed. FREO2 Foundation Australia has developed an integrated oxygen system, driven by a mains-powered oxygen concentrator, with the ability to switch automatically between low-pressure oxygen storage device and cylinder oxygen in power interruptions. The aim of this study is to assess the clinical impact and cost-effectiveness of expanding this system to 20 community and district hospitals and level IV facilities in Western Uganda.Methods and analysis This will be a phased implementation with preintervention and postintervention comparison of outcomes. Standardised baseline data collection and needs assessment will be conducted, followed by implementation of the FREO2 Oxygen System in combination with pulse oximetry in 1–2 facilities per month over a 16-month period, with a total 23-month data collection period. The primary outcome will be the proportion of hypoxaemic children receiving oxygen pre and post oxygen system. Secondary outcomes will assess clinical, economic and technical aspects. Pre and post oxygen system primary and secondary outcomes will be compared using regression models and standard tests of significance. Useability will be quantitatively and qualitatively evaluated in terms of acceptability, feasibility and appropriateness, using standardised implementation outcome measure tools.Ethics and dissemination Ethics approval was obtained from Mbarara University of Science and Technology (MUREC 1/7) and the University of Melbourne (2021-14489-13654-2). Outcomes will be presented to the involved facilities, and to representatives of the Ministry of Health, Uganda. Broader dissemination will include publication in peer-reviewed journals and academic conference presentations.Trial registration number ACTRN12621000241831. |
| format | Article |
| id | doaj-art-547eb73726994c55ba426bad3d828675 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-547eb73726994c55ba426bad3d8286752025-01-28T05:50:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-054642Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wardsGraham Moore0Hamish Graham1Rami Subhi2Sheillah Bagayana3Joseph Mugerwa4David Peake5Eleanor Nakintu6Daniel Murokora7Roger Rassool8Marc Sklar9Bryn Sobott10Wolfson Centre for Young People`s Mental Health, Cardiff University, Cardiff, UKCentre for International Child Health, University of Melbourne, MCRI, Royal Children’s Hospital, Parkville, Victoria, AustraliaThe University of Melbourne - Parkville Campus, Melbourne, Victoria, AustraliaFREO2 Foundation, Kampala, UgandaFREO2 Foundation, Kampala, UgandaFREO2 Foundation, Melbourne, Victoria, AustraliaBrick by Brick, Kalisizo, UgandaBrick by Brick, Kalisizo, UgandaFREO2 Foundation, Melbourne, Victoria, AustraliaBrick by Brick, New York City, New York, USAFREO2 Foundation, Melbourne, Victoria, AustraliaIntroduction Oxygen is an essential medicine for children and adults. The current systems for its delivery can be expensive and unreliable in settings where oxygen is most needed. FREO2 Foundation Australia has developed an integrated oxygen system, driven by a mains-powered oxygen concentrator, with the ability to switch automatically between low-pressure oxygen storage device and cylinder oxygen in power interruptions. The aim of this study is to assess the clinical impact and cost-effectiveness of expanding this system to 20 community and district hospitals and level IV facilities in Western Uganda.Methods and analysis This will be a phased implementation with preintervention and postintervention comparison of outcomes. Standardised baseline data collection and needs assessment will be conducted, followed by implementation of the FREO2 Oxygen System in combination with pulse oximetry in 1–2 facilities per month over a 16-month period, with a total 23-month data collection period. The primary outcome will be the proportion of hypoxaemic children receiving oxygen pre and post oxygen system. Secondary outcomes will assess clinical, economic and technical aspects. Pre and post oxygen system primary and secondary outcomes will be compared using regression models and standard tests of significance. Useability will be quantitatively and qualitatively evaluated in terms of acceptability, feasibility and appropriateness, using standardised implementation outcome measure tools.Ethics and dissemination Ethics approval was obtained from Mbarara University of Science and Technology (MUREC 1/7) and the University of Melbourne (2021-14489-13654-2). Outcomes will be presented to the involved facilities, and to representatives of the Ministry of Health, Uganda. Broader dissemination will include publication in peer-reviewed journals and academic conference presentations.Trial registration number ACTRN12621000241831.https://bmjopen.bmj.com/content/12/6/e054642.full |
| spellingShingle | Graham Moore Hamish Graham Rami Subhi Sheillah Bagayana Joseph Mugerwa David Peake Eleanor Nakintu Daniel Murokora Roger Rassool Marc Sklar Bryn Sobott Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards BMJ Open |
| title | Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards |
| title_full | Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards |
| title_fullStr | Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards |
| title_full_unstemmed | Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards |
| title_short | Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards |
| title_sort | technology to improve reliable access to oxygen in western uganda study protocol for a phased implementation trial in neonatal and paediatric wards |
| url | https://bmjopen.bmj.com/content/12/6/e054642.full |
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