Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome
Introduction. Fractalkine is a chemokine associated with atherosclerosis. Increased serum levels have been reported in unstable coronary artery disease (CAD) and to predict mortality in heart failure. Mediterranean-like diet and omega-3 fatty acids (n3-PUFA) have documented cardioprotective and anti...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/373070 |
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| author | Kristian Laake Ingebjørg Seljeflot Morten Wang Fagerland Ida Unhammer Njerve Harald Arnesen Svein Solheim |
| author_facet | Kristian Laake Ingebjørg Seljeflot Morten Wang Fagerland Ida Unhammer Njerve Harald Arnesen Svein Solheim |
| author_sort | Kristian Laake |
| collection | DOAJ |
| description | Introduction. Fractalkine is a chemokine associated with atherosclerosis. Increased serum levels have been reported in unstable coronary artery disease (CAD) and to predict mortality in heart failure. Mediterranean-like diet and omega-3 fatty acids (n3-PUFA) have documented cardioprotective and anti-inflammatory effects. We have investigated the effect of Mediterranean-like dietary counseling and n-3 PUFA on serum fractalkine in an elderly population and its ability to predict cardiovascular disease (CVD). Materials and Methods. 563 men (age 64–75 yrs) at high risk of CAD were randomized into a 2 × 2 factorial designed trial for 3-year dietary counseling and/or n-3 PUFA supplementation (2.4 g/d). Circulating levels of fractalkine were measured at baseline and at end of study. Clinical events were recorded after 3 years. Results. Fractalkine levels were significantly reduced in all groups from baseline to 3 years (P<0.001, all), but without between-group differences in changes. Fractalkine levels at baseline were not predictive for CVD events (n=68) or total mortality. Lower fractalkine levels were observed in smokers (P=0.019). Conclusions. Reduced levels of fractalkine from baseline to 3 years were observed, however, without any influence of Mediterranean-like diet or n-3 PUFA supplementation. Fractalkine levels at baseline were not predictive for later CVD events. |
| format | Article |
| id | doaj-art-5466b133dee5409c900ebced585cee27 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5466b133dee5409c900ebced585cee272025-02-03T01:27:11ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/373070373070Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical OutcomeKristian Laake0Ingebjørg Seljeflot1Morten Wang Fagerland2Ida Unhammer Njerve3Harald Arnesen4Svein Solheim5Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Postboks 4956 Nydalen, 0424 Oslo, NorwayCenter for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Postboks 4956 Nydalen, 0424 Oslo, NorwayOslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, NorwayCenter for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Postboks 4956 Nydalen, 0424 Oslo, NorwayCenter for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Postboks 4956 Nydalen, 0424 Oslo, NorwayCenter for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Postboks 4956 Nydalen, 0424 Oslo, NorwayIntroduction. Fractalkine is a chemokine associated with atherosclerosis. Increased serum levels have been reported in unstable coronary artery disease (CAD) and to predict mortality in heart failure. Mediterranean-like diet and omega-3 fatty acids (n3-PUFA) have documented cardioprotective and anti-inflammatory effects. We have investigated the effect of Mediterranean-like dietary counseling and n-3 PUFA on serum fractalkine in an elderly population and its ability to predict cardiovascular disease (CVD). Materials and Methods. 563 men (age 64–75 yrs) at high risk of CAD were randomized into a 2 × 2 factorial designed trial for 3-year dietary counseling and/or n-3 PUFA supplementation (2.4 g/d). Circulating levels of fractalkine were measured at baseline and at end of study. Clinical events were recorded after 3 years. Results. Fractalkine levels were significantly reduced in all groups from baseline to 3 years (P<0.001, all), but without between-group differences in changes. Fractalkine levels at baseline were not predictive for CVD events (n=68) or total mortality. Lower fractalkine levels were observed in smokers (P=0.019). Conclusions. Reduced levels of fractalkine from baseline to 3 years were observed, however, without any influence of Mediterranean-like diet or n-3 PUFA supplementation. Fractalkine levels at baseline were not predictive for later CVD events.http://dx.doi.org/10.1155/2015/373070 |
| spellingShingle | Kristian Laake Ingebjørg Seljeflot Morten Wang Fagerland Ida Unhammer Njerve Harald Arnesen Svein Solheim Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome Mediators of Inflammation |
| title | Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome |
| title_full | Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome |
| title_fullStr | Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome |
| title_full_unstemmed | Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome |
| title_short | Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome |
| title_sort | effects on serum fractalkine by diet and omega 3 fatty acid intervention relation to clinical outcome |
| url | http://dx.doi.org/10.1155/2015/373070 |
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