Donor-derived cell-free DNA for detection of acute rejection in lung transplant recipients

Donor-derived cell-free DNA for detection of acute rejection in lung transplant recipients

IntroductionAcute rejection is a significant risk factor for developing chronic lung allograft dysfunction. Current monitoring tools, transbronchial biopsies and HLA antibody determination, have limitations in detecting acute rejection. This study aims to explore the potential utility of donor-deriv...

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Bibliographic Details
Main Authors: Gökce Yavuz, Julia Walter, Kaimo Hirv, Oliver Wachter, Andrea Dick, Julia Kovacs, Julia Zimmermann, Olaf M. Glueck, Maximilian Vorstandlechner, Nicole Samm, Jan M. Fertmann, Wulf Sienel, Sebastian Michel, Michael Irlbeck, Nikolaus Kneidinger, Rudolf Hatz, Jürgen Behr, Christian Schneider, Teresa Kauke
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
ddcfDNA
acute cellular rejection
antibody mediated rejection
allograft injury
lung transplantation
non-invasive biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531774/full
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