In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus
Mushrooms have great potential to be used as food and pharmaceutical sources. Most of the non-edible mushrooms contain biologically active metabolites that are functional for modern medicinal applications. Within the present study, anticoagulant and antiinflammatory activities of Geastrum fimbriatum...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
izzet kara
2019-03-01
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| Series: | International Journal of Secondary Metabolite |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/pub/ijsm/issue/41604/454836?publisher=ijate |
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| Summary: | Mushrooms have great potential to be used as food and
pharmaceutical sources. Most of the non-edible mushrooms contain biologically
active metabolites that are functional for modern medicinal applications.
Within the present study, anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr. (Syn. Geastrum sessile (Sowerby) Pouzar), a
mushroom naturally grown in Turkey, were investigated. The in vitro anticoagulant activity of the ethanolic extract obtained
with a soxhlet apparatus determined by activated partial thromboplastin time (APTT) and
prothrombin time (PT) assays using commercial reagents. The
antiinflammatory activity of the extract was determined by lipoxygenase
inhibition assay. When
compared with the negative control DMSO, G.
fimbriatum extract exhibited significant anticoagulant effects in
the APTT test that evaluates the intrinsic coagulation pathway. The ethanolic
extract found to prolong the coagulation time. However, no inhibition was
observed in the PT test which evaluates the extrinsic coagulation pathway, The
extract showed 12.92% inhibition on the lipoxygenase enzyme activity. Overall, G. fimbriatum ethanolic extract
exhibited potent antiinflammatory activity besides being a potential source of
anticoagulant. Further analysis is
required to evaluate the medical use of Geastrum
mushrooms from a pharmaceutical point of view. |
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| ISSN: | 2148-6905 |