Development of a chemotactic SynCom bioorganic fertilizer for biocontrol of bacterial wilt in tobacco fields

Abstract Bacterial wilt caused by Ralstonia solanacearum is one of the most severe plant diseases all over the world. Currently, many scientists are using SynCom (synthetic microbial community) to control this disease. However, designing of highly efficient SynCom remains challenging. In this study,...

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Main Authors: Yanxia Liu, Weiqi Zhang, Li Guo, Han Li, Jingwei Zhu, Xiang Li, Xiaoni Zhang, Xinrun Yang, Yangchun Xu, Qirong Shen, Tianjie Yang, Zhong Wei
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Applied Microbiology and Biotechnology
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Online Access:https://doi.org/10.1007/s00253-025-13547-6
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Summary:Abstract Bacterial wilt caused by Ralstonia solanacearum is one of the most severe plant diseases all over the world. Currently, many scientists are using SynCom (synthetic microbial community) to control this disease. However, designing of highly efficient SynCom remains challenging. In this study, we isolated 372 bacteria with different morphologies from the rhizosphere soil of healthy tobacco plants in a diseased field. Based on the antagonistic activity, compatibility, and presence of cheA gene, a marker gene of chemotaxis, we constructed a chemotactic SynCom comprising two Pseudomonas strains and one Bacillus strain. In vitro experiments revealed that vitamin C, propionic acid, and esculetin significantly promoted the growth and antagonistic ability of chemotactic SynCom strains. Next, we optimized the proportion of organic fertilizer to support the growth of the SynCom strains. The application of the bioorganic fertilizer containing chemotactic SynCom can protect diseased tobacco field from R. solanacearum invasion and enhance yields. Finally, rhizosphere bacterial community analysis showed that phyla Bacillota and Chloroflexiota were significantly enriched. This study highlights the potential of chemotactic SynCom for effective biocontrol, offering a new approach for managing bacterial wilt and enhancing crop yields. Graphical Abstract Key points • The bioorganic fertilizer containing chemotactic SynCom suppresses R. solanacearum and boosts tobacco yields. • Root exudate-selected prebiotics enhance the antagonistic effects of SynCom against pathogens. • SynCom bioorganic fertilizer regulates the rhizosphere microbiome, enriching beneficial bacterial phyla.
ISSN:1432-0614